{"id":"3b139ae3-e4dd-5b76-93a8-be2c5d5265de","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-rbc-oxidation","predicate":"reduces","statement":"In 30 middle-aged and older adults, 6 or 12 mg/day for 12 weeks increased erythrocyte astaxanthin and reduced erythrocyte phospholipid hydroperoxides.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b55cd984-ca47-538a-9e47-f2d8a3d08e57","mechanism_event_label":"Blood-cell exposure and an oxidation marker changed together.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"f6c4a832-9648-54f1-93f1-011768bfa497","slug":"human-astaxanthin-rbc-peroxidation","display_name":"Human erythrocyte phospholipid hydroperoxides after astaxanthin","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b55cd984-ca47-538a-9e47-f2d8a3d08e57","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-rbc-oxidation-event","event_type":"observed_relationship","label":"Blood-cell exposure and an oxidation marker changed together.","description":"In 30 middle-aged and older adults, 6 or 12 mg/day for 12 weeks increased erythrocyte astaxanthin and reduced erythrocyte phospholipid hydroperoxides.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f6c4a832-9648-54f1-93f1-011768bfa497","slug":"human-astaxanthin-rbc-peroxidation","display_name":"Human erythrocyte phospholipid hydroperoxides after astaxanthin","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human supplementation trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"An erythrocyte marker does not demonstrate prevention of dementia or protection in every tissue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Blood-cell exposure and an oxidation marker changed together.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21276280/ · DOI 10.1017/S0007114510005398","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"30470c09-6308-5ab1-9816-10836cf659c7","evidence_kind":"source_excerpt","locator":"Lines 414-420","start_line":414,"end_line":420,"excerpt":"## astaxanthin-rbc-oxidation\nBlood-cell exposure and an oxidation marker changed together.\nIn 30 middle-aged and older adults, 6 or 12 mg/day for 12 weeks increased erythrocyte astaxanthin and reduced erythrocyte phospholipid hydroperoxides.\nModel: Human supplementation trial.\nLimitations: An erythrocyte marker does not demonstrate prevention of dementia or protection in every tissue.\nEvidence access: Primary abstract\nAntioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21276280/ · DOI 10.1017/S0007114510005398","model_system":"Human supplementation trial.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"98640e32f62e6c0387578165342ad21b3d2325701fcfdbb5c48886c783040e5e","revision_id":"a82757ce-1feb-582c-a5fc-f7de36308f1f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}