{"id":"3b056ae8-6050-58af-92bc-204c15707efa","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-mouse-fgf","predicate":"induces","statement":"PPARalpha directly induced hepatic FGF21 in response to fasting or agonists.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b53d5bf2-fd6c-5986-ac68-d9feb5bdde56","mechanism_event_label":"A fat-sensing regulator activated an endocrine signal.","subject":{"id":"82da9a4a-69b5-5680-abb1-5fa6d0df95a0","slug":"mouse-ppara","display_name":"Mouse peroxisome proliferator-activated receptor alpha / Ppara","entity_type_key":"protein"},"object":{"id":"8b01fe3c-a32b-5076-9c61-34d4d35e8b89","slug":"mouse-fgf21","display_name":"Mouse fibroblast growth factor 21 / Fgf21","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"b53d5bf2-fd6c-5986-ac68-d9feb5bdde56","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-mouse-fgf-event","event_type":"observed_relationship","label":"A fat-sensing regulator activated an endocrine signal.","description":"PPARalpha directly induced hepatic FGF21 in response to fasting or agonists.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"82da9a4a-69b5-5680-abb1-5fa6d0df95a0","slug":"mouse-ppara","display_name":"Mouse peroxisome proliferator-activated receptor alpha / Ppara","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8b01fe3c-a32b-5076-9c61-34d4d35e8b89","slug":"mouse-fgf21","display_name":"Mouse fibroblast growth factor 21 / Fgf21","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse fasting, agonist and FGF21 experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Species-specific experimental evidence; not a human fasting timer.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"A fat-sensing regulator activated an endocrine signal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17550777/ · DOI 10.1016/j.cmet.2007.05.003","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"711ef918-26db-56d0-a2dc-2fcc2a6297fd","evidence_kind":"source_excerpt","locator":"Lines 240-246","start_line":240,"end_line":246,"excerpt":"## fast-mouse-fgf\nA fat-sensing regulator activated an endocrine signal.\nPPARalpha directly induced hepatic FGF21 in response to fasting or agonists.\nModel: Mouse fasting, agonist and FGF21 experiments.\nLimitations: Species-specific experimental evidence; not a human fasting timer.\nEvidence access: Primary abstract\nEndocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17550777/ · DOI 10.1016/j.cmet.2007.05.003","model_system":"Mouse fasting, agonist and FGF21 experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}