{"id":"3afefb0f-caf1-5526-b9b8-f8f1526b60a9","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-initial-symptoms","predicate":"increases_initial_reported","statement":"In 130 self-reported MSG-reactive volunteers given 5 g without food, 50 responded to MSG only, 17 to placebo only and 19 to both.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"08a077b7-99fc-54b6-9921-a304e3487fc3","mechanism_event_label":"The initial challenge showed more symptoms after MSG than placebo.","subject":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"object":{"id":"0868ad97-9dad-5927-b402-95a6ba025ba7","slug":"human-msg-challenge-symptoms","display_name":"Human symptoms during blinded MSG challenge","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"08a077b7-99fc-54b6-9921-a304e3487fc3","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-initial-symptoms-event","event_type":"observed_relationship","label":"The initial challenge showed more symptoms after MSG than placebo.","description":"In 130 self-reported MSG-reactive volunteers given 5 g without food, 50 responded to MSG only, 17 to placebo only and 19 to both.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0868ad97-9dad-5927-b402-95a6ba025ba7","slug":"human-msg-challenge-symptoms","display_name":"Human symptoms during blinded MSG challenge","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Multicenter blinded crossover; positive response required at least two listed symptoms within two hours.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Self-selected group and acute bolus; molecular cause was not identified.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Monosodium Glutamate (MSG) collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The initial challenge showed more symptoms after MSG than placebo.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Multicenter, double-blind, placebo-controlled, multiple-challenge evaluation of reported reactions to monosodium glutamate. · 2000 · https://pubmed.ncbi.nlm.nih.gov/11080723/ · DOI 10.1067/mai.2000.110794","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"55f9406f-77d5-5d51-8d3a-4aa876185470","evidence_kind":"source_excerpt","locator":"Lines 258-264","start_line":258,"end_line":264,"excerpt":"## monosodium-glutamate-initial-symptoms\nThe initial challenge showed more symptoms after MSG than placebo.\nIn 130 self-reported MSG-reactive volunteers given 5 g without food, 50 responded to MSG only, 17 to placebo only and 19 to both.\nModel: Multicenter blinded crossover; positive response required at least two listed symptoms within two hours.\nLimitations: Self-selected group and acute bolus; molecular cause was not identified.\nEvidence access: Primary abstract\nMulticenter, double-blind, placebo-controlled, multiple-challenge evaluation of reported reactions to monosodium glutamate. · 2000 · https://pubmed.ncbi.nlm.nih.gov/11080723/ · DOI 10.1067/mai.2000.110794","model_system":"Multicenter blinded crossover; positive response required at least two listed symptoms within two hours.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"90a81fe5-8622-52f6-b4db-04899206c2b0","stable_key":"import-561b2b40-5b59-548f-a749-f357f7e2304c","title":"Monosodium Glutamate (MSG): taste, gut sensing, exposure and cross-nutrient mechanisms (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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