{"id":"3ad4b5d8-482c-56a3-97f4-4a69a09d1d06","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-beta-block","predicate":"attenuates_caffeine_response","statement":"With propranolol, caffeine-associated insulin and C-peptide responses resembled placebo.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"6451d763-0b6b-56ae-a261-fe5b73c726ac","mechanism_event_label":"Blocking beta-adrenergic signaling removed the response in this test.","subject":{"id":"01b9c67d-436d-523a-8f78-53cad2b521ce","slug":"propranolol","display_name":"Propranolol","entity_type_key":"small_molecule"},"object":{"id":"dadeffad-d96b-5b27-8812-0fc9cac0db4e","slug":"ogtt-insulin-response","display_name":"Insulin response during an oral glucose tolerance test","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6451d763-0b6b-56ae-a261-fe5b73c726ac","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-beta-block-event","event_type":"observed_relationship","label":"Blocking beta-adrenergic signaling removed the response in this test.","description":"With propranolol, caffeine-associated insulin and C-peptide responses resembled placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"01b9c67d-436d-523a-8f78-53cad2b521ce","slug":"propranolol","display_name":"Propranolol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"dadeffad-d96b-5b27-8812-0fc9cac0db4e","slug":"ogtt-insulin-response","display_name":"Insulin response during an oral glucose tolerance test","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7f5bdfe9-54d7-5cfc-86d9-10c23bdfa290","slug":"epinephrine","display_name":"Epinephrine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Seven healthy men; 5 mg/kg caffeine, 80 mg propranolol, combination or placebo before an oral glucose tolerance test.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small acute experiment. Beta blockade supports an adrenergic contribution, not proof that it is the only mechanism or that a blocker should be used to counter caffeine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Caffeine collection; salts, coffee, species and coexposure contexts retain their identities.","comparator":null,"unit":null,"notes":"","entity":{"slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Blocking beta-adrenergic signaling removed the response in this test.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Caffeine-induced impairment of glucose tolerance is abolished by beta-adrenergic receptor blockade in humans. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12015346/ · DOI 10.1152/japplphysiol.01229.2001","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a15de505-eed4-5f68-aede-d6a1d7f468f0","evidence_kind":"source_excerpt","locator":"Lines 500-506","start_line":500,"end_line":506,"excerpt":"## caf-beta-block\nBlocking beta-adrenergic signaling removed the response in this test.\nWith propranolol, caffeine-associated insulin and C-peptide responses resembled placebo.\nModel: Seven healthy men; 5 mg/kg caffeine, 80 mg propranolol, combination or placebo before an oral glucose tolerance test.\nLimitations: Small acute experiment. Beta blockade supports an adrenergic contribution, not proof that it is the only mechanism or that a blocker should be used to counter caffeine.\nEvidence access: Primary abstract\nCaffeine-induced impairment of glucose tolerance is abolished by beta-adrenergic receptor blockade in humans. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12015346/ · DOI 10.1152/japplphysiol.01229.2001","model_system":"Seven healthy men; 5 mg/kg caffeine, 80 mg propranolol, combination or placebo before an oral glucose tolerance test.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access stated with the claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"40a654db-878c-5471-bc6c-88f4f52599c0","stable_key":"import-ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6","title":"Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"780d73d4abd45a0284d2cc0c646dbe8432ae347362891a4b98a19a61341a7325","revision_id":"f36ffb0a-d6df-522f-b783-5e30214b9e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}