{"id":"3a8c4cf1-5955-57a2-8810-0ab8d1d4122a","stable_key":"548ab9d6-3a9b-5bed-879c-17d03813b636:b2-baboon-pyridine-nucleotide-boundary","predicate":"does-not-necessarily-determine","statement":"Red-cell pyridine nucleotides decreased in pyridoxine-deficient baboons, but not in the riboflavin-deficient group.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"5c7f5e9f-995f-585e-b45f-b05a8721a569","mechanism_event_label":"The B2-related urine change did not establish a fall in this red-cell nucleotide pool.","subject":{"id":"86eb1eee-a8d1-539c-8c17-0911f69b6f1b","slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"},"object":{"id":"1820aabe-fe65-5c20-8bd8-e3b66bc4d397","slug":"erythrocyte-pyridine-nucleotide-content","display_name":"Erythrocyte pyridine nucleotide content","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5c7f5e9f-995f-585e-b45f-b05a8721a569","stable_key":"548ab9d6-3a9b-5bed-879c-17d03813b636:b2-baboon-pyridine-nucleotide-boundary-event","event_type":"observed_intervention","label":"The B2-related urine change did not establish a fall in this red-cell nucleotide pool.","description":"Red-cell pyridine nucleotides decreased in pyridoxine-deficient baboons, but not in the riboflavin-deficient group.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"283ed24b-06a1-50aa-9281-df3bac6ce37e","slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"},"role":"component of pyridine-nucleotide pool","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"be6e4670-953f-5a4e-97da-1e536a54e0e4","slug":"nadp-plus","display_name":"NADP+","entity_type_key":"small_molecule"},"role":"component of pyridine-nucleotide pool","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"86eb1eee-a8d1-539c-8c17-0911f69b6f1b","slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"1820aabe-fe65-5c20-8bd8-e3b66bc4d397","slug":"erythrocyte-pyridine-nucleotide-content","display_name":"Erythrocyte pyridine nucleotide content","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Prevents equating altered tryptophan metabolism with universal niacin depletion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Dietary riboflavin-deficient, pyridoxine-deficient, pair-fed and natural-diet baboons; urinary and erythrocyte measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Experimental riboflavin-deficient diet","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The abstract reports an aggregate red-cell readout; it does not resolve synthesis flux, other tissues or every NAD species.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Riboflavin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Papio species (baboon)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The B2-related urine change did not establish a fall in this red-cell nucleotide pool.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[verjee1975] Tryptophan metabolism in baboons: effect of riboflavin and pyridoxine deficiency. (1975). https://pubmed.ncbi.nlm.nih.gov/23659/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Erythrocytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"3ad1411a-88a7-58db-ae10-9cf717c4a38b","evidence_kind":"source_excerpt","locator":"Lines 1290-1302","start_line":1290,"end_line":1302,"excerpt":"### b2-baboon-pyridine-nucleotide-boundary\nRed-cell pyridine nucleotides decreased in pyridoxine-deficient baboons, but not in the riboflavin-deficient group.\nCondition category: nutrient_deficiency\nnutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The B2-related urine change did not establish a fall in this red-cell nucleotide pool.\norganism: Papio species (baboon)\ntissue_or_cell_type: Erythrocytes\nexperimental_model: Dietary riboflavin-deficient, pyridoxine-deficient, pair-fed and natural-diet baboons; urinary and erythrocyte measurements.\nlimitations: The abstract reports an aggregate red-cell readout; it does not resolve synthesis flux, other tissues or every NAD species.\nexposure: Experimental riboflavin-deficient diet\ncross_nutrient: Prevents equating altered tryptophan metabolism with universal niacin depletion.\nevidence_location: Abstract\n[verjee1975] Tryptophan metabolism in baboons: effect of riboflavin and pyridoxine deficiency. (1975). https://pubmed.ncbi.nlm.nih.gov/23659/","model_system":"Dietary riboflavin-deficient, pyridoxine-deficient, pair-fed and natural-diet baboons; urinary and erythrocyte measurements.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [verjee1975] Tryptophan metabolism in baboons: effect of riboflavin and pyridoxine deficiency. (1975). https://pubmed.ncbi.nlm.nih.gov/23659/","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4f7c9578-82bf-5e2d-b5c4-72a79fb4f6af","stable_key":"import-548ab9d6-3a9b-5bed-879c-17d03813b636","title":"Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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