{"id":"3a4e75e0-6d29-5be6-a4c6-18493fff14de","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-yogurt-timing","predicate":"increases_in_recorded_comparison","statement":"The yogurt/parsley preparation shifted observed conjugate peaks to the last sampled point at 6 hours or later, compared with 4 hours for the drink.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"fd5c89f2-b229-513c-b301-5b54aebfdb4f","mechanism_event_label":"The yogurt/parsley preparation shifted observed conjugate peaks to the last sampled point at 6 hours or later, compared with 4 hours for the drink.","subject":{"id":"b9776af8-1f54-5658-84a5-9a129f8f88d8","slug":"apigenin-parsley-yogurt-2022","display_name":"Parsley with yogurt in the 2022 apigenin metabolism study","entity_type_key":"botanical"},"object":{"id":"aa3e4a4f-c66e-5d04-ac32-c78406e9233d","slug":"apigenin-conjugate-plasma-timing","display_name":"Human apigenin-conjugate plasma timing","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fd5c89f2-b229-513c-b301-5b54aebfdb4f","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-yogurt-timing-event","event_type":"experimental_observation","label":"The yogurt/parsley preparation shifted observed conjugate peaks to the last sampled point at 6 hours or later, compared with 4 hours for the drink.","description":"### api-yogurt-timing\n\nThe yogurt/parsley preparation shifted observed conjugate peaks to the last sampled point at 6 hours or later, compared with 4 hours for the drink.\nSection 3.3.3; urinary recovery was not significantly different. Gastric emptying and matrix release were proposed explanations, not measured causal mediators.\nModel and exposure: Four men, 118 micromoles apiin with 100 g yogurt.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults. | 2022 | https://pubmed.ncbi.nlm.nih.gov/35452808/ | https://doi.org/10.1016/j.freeradbiomed.2022.04.007 | Access: Full original primary-paper PDF, Methods, Results and Tables 1–7 reviewed; authentic-standard HPLC-MS analysis. PDF obtained from a public mirror; DOI and article identity verified.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b9776af8-1f54-5658-84a5-9a129f8f88d8","slug":"apigenin-parsley-yogurt-2022","display_name":"Parsley with yogurt in the 2022 apigenin metabolism study","entity_type_key":"botanical"},"role":"tested factor","stoichiometry":null,"state_label":"Parsley with yogurt","sequence_order":0,"notes":""},{"entity":{"id":"aa3e4a4f-c66e-5d04-ac32-c78406e9233d","slug":"apigenin-conjugate-plasma-timing","display_name":"Human apigenin-conjugate plasma timing","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"increase","sequence_order":1,"notes":""},{"entity":{"id":"a59463a8-fad3-5138-9f17-42f226d1c220","slug":"apiin","display_name":"Apiin / apigenin 7-O-apiosylglucoside","entity_type_key":"small_molecule"},"role":"matched glycoside","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"070686a8-425a-59da-b2d4-cacd7f73b711","slug":"apigenin-4-prime-glucuronide","display_name":"Apigenin 4′-O-glucuronide","entity_type_key":"small_molecule"},"role":"measured product","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"362acc8e-822f-59c4-abbc-e1f9f5b1bbe4","slug":"apigenin-7-sulfate","display_name":"Apigenin 7-O-sulfate","entity_type_key":"small_molecule"},"role":"measured product","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Full original primary-paper PDF, Methods, Results and Tables 1–7 reviewed; authentic-standard HPLC-MS analysis. PDF obtained from a public mirror; DOI and article identity verified.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Parsley with yogurt\", \"comparator\": \"Parsley drink\", \"endpoint\": \"The yogurt/parsley preparation shifted observed conjugate peaks to the last sampled point at 6 hours or later, compared with 4 hours for the drink.\", \"effect_direction\": \"increase\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; recorded from source.","entity":null},{"dimension":"experimental_model","value_text":"Four men, 118 micromoles apiin with 100 g yogurt.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Apigenin collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The yogurt/parsley preparation shifted observed conjugate peaks to the last sampled point at 6 hours or later, compared with 4 hours for the drink.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults. | https://pubmed.ncbi.nlm.nih.gov/35452808/ | https://doi.org/10.1016/j.freeradbiomed.2022.04.007","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference api-yogurt-timing; Section 3.3.3; urinary recovery was not significantly different. Gastric emptying and matrix release were proposed explanations, not measured causal mediators.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"caa83565-3aba-52c5-85ba-7ee5afe550e7","evidence_kind":"source_excerpt","locator":"Lines 69-75","start_line":69,"end_line":75,"excerpt":"### api-yogurt-timing\n\nThe yogurt/parsley preparation shifted observed conjugate peaks to the last sampled point at 6 hours or later, compared with 4 hours for the drink.\nSection 3.3.3; urinary recovery was not significantly different. Gastric emptying and matrix release were proposed explanations, not measured causal mediators.\nModel and exposure: Four men, 118 micromoles apiin with 100 g yogurt.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults. | 2022 | https://pubmed.ncbi.nlm.nih.gov/35452808/ | https://doi.org/10.1016/j.freeradbiomed.2022.04.007 | Access: Full original primary-paper PDF, Methods, Results and Tables 1–7 reviewed; authentic-standard HPLC-MS analysis. PDF obtained from a public mirror; DOI and article identity verified.","model_system":"Four men, 118 micromoles apiin with 100 g yogurt.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"54eac90b-add1-5f56-9036-d900307c5697","stable_key":"import-ff370329-68a3-573d-96ee-597de78a3967","title":"Apigenin: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"ede6e5c6b91d66b66844f2ff667a7f8303d9ac1281f15dc09db703f7de4da942","revision_id":"b41a39a2-0197-549c-97a5-1765e6696931","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}