{"id":"3a140471-c9fb-5ec9-93ad-16b1f282d1fa","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-mouse-late-life","predicate":"extends","statement":"Late-life fisetin administration extended median and maximum lifespan in the reported wild-type mouse experiment.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"edfd4095-8b66-51e5-82ef-35bd36642d15","mechanism_event_label":"An animal survival result warrants separate clinical testing.","subject":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"object":{"id":"18aa0cdb-9fd3-5b36-b1cd-1fa8d9220a90","slug":"mouse-fisetin-late-life-survival","display_name":"Mouse survival during late-life fisetin intervention","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"edfd4095-8b66-51e5-82ef-35bd36642d15","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-mouse-late-life-event","event_type":"observed_relationship","label":"An animal survival result warrants separate clinical testing.","description":"Late-life fisetin administration extended median and maximum lifespan in the reported wild-type mouse experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"18aa0cdb-9fd3-5b36-b1cd-1fa8d9220a90","slug":"mouse-fisetin-late-life-survival","display_name":"Mouse survival during late-life fisetin intervention","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Naturally aged mice; dietary intervention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not established human longevity; multiple endpoints share the same study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An animal survival result warrants separate clinical testing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Fisetin is a senotherapeutic that extends health and lifespan. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30279143/ · DOI 10.1016/j.ebiom.2018.09.015","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a1d714c4-d6b0-5739-ac60-43b9214d632f","evidence_kind":"source_excerpt","locator":"Lines 224-230","start_line":224,"end_line":230,"excerpt":"## fisetin-mouse-late-life\nAn animal survival result warrants separate clinical testing.\nLate-life fisetin administration extended median and maximum lifespan in the reported wild-type mouse experiment.\nModel: Naturally aged mice; dietary intervention.\nLimitations: Not established human longevity; multiple endpoints share the same study.\nEvidence access: Primary abstract\nFisetin is a senotherapeutic that extends health and lifespan. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30279143/ · DOI 10.1016/j.ebiom.2018.09.015","model_system":"Naturally aged mice; dietary intervention.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1108bfff-6504-5152-a51f-ff3d7c27c282","stable_key":"import-74ef5bba-ee14-531c-b1bf-d1f297c56bb6","title":"Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c30e0764cd34bd062cfcbfaf32357ef29dfda30e7d4153c545178140f5054e09","revision_id":"40ff52c0-f4b9-5820-8abb-ff002c6364a4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}