{"id":"39c230b9-2606-5830-8136-f67709e1b349","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-diabetes-clamp-trial2024","predicate":"did_not_significantly_change","statement":"Magnesium increased serum Mg but did not significantly change the primary clamp outcome in insulin-treated adults with low serum Mg.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2d8d314f-5ad2-5a68-91d4-2c8e82e70b7b","mechanism_event_label":"Raising the blood magnesium value did not establish improved insulin sensitivity in this trial.","subject":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"object":{"id":"c762a547-5e1f-5023-9026-4ad8a9fc93b0","slug":"clamp-glucose-infusion-rate","display_name":"Hyperinsulinemic-euglycemic clamp glucose infusion rate","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2d8d314f-5ad2-5a68-91d4-2c8e82e70b7b","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-diabetes-clamp-trial2024-event","event_type":"observed_intervention","label":"Raising the blood magnesium value did not establish improved insulin sensitivity in this trial.","description":"Magnesium increased serum Mg but did not significantly change the primary clamp outcome in insulin-treated adults with low serum Mg.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"role":"background_treatment_and_clamp_signal","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8ae7848b-f172-5e09-8acf-5ca914907b0b","slug":"glucose","display_name":"D-glucose","entity_type_key":"small_molecule"},"role":"clamp_substrate","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"c762a547-5e1f-5023-9026-4ad8a9fc93b0","slug":"clamp-glucose-infusion-rate","display_name":"Hyperinsulinemic-euglycemic clamp glucose infusion rate","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Magnesium/insulin/glucose: biochemical repletion and clinical response are separate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"14-person, six-week randomized crossover trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"15 mmol/day trial exposure, not advice. Clamp M 4.6 versus 4.4 mg/kg/min; p=0.108.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small trial and modest biochemical change; not proof of zero effect. Differs from the 2003 trial in treatment, duration and endpoint, not a fabricated scientific contradiction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Raising the blood magnesium value did not establish improved insulin sensitivity in this trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mg-drenthen2024] Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial (2024). https://pubmed.ncbi.nlm.nih.gov/37922013/ DOI: 10.1007/s00125-023-06029-9","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human whole-body glucose clamp and blood measurements","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"adf2c43b-0423-59d8-a683-7c9d3197868f","evidence_kind":"source_excerpt","locator":"Lines 1564-1575","start_line":1564,"end_line":1575,"excerpt":"### mg-diabetes-clamp-trial2024\nMagnesium increased serum Mg but did not significantly change the primary clamp outcome in insulin-treated adults with low serum Mg.\nCondition category: normal\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Raising the blood magnesium value did not establish improved insulin sensitivity in this trial.\norganism: Homo sapiens\ntissue_or_cell_type: Human whole-body glucose clamp and blood measurements\nexperimental_model: 14-person, six-week randomized crossover trial.\nlimitations: Small trial and modest biochemical change; not proof of zero effect. Differs from the 2003 trial in treatment, duration and endpoint, not a fabricated scientific contradiction.\ncross_nutrient: Magnesium/insulin/glucose: biochemical repletion and clinical response are separate.\nexposure: 15 mmol/day trial exposure, not advice. Clamp M 4.6 versus 4.4 mg/kg/min; p=0.108.\n[mg-drenthen2024] Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial (2024). https://pubmed.ncbi.nlm.nih.gov/37922013/ DOI: 10.1007/s00125-023-06029-9","model_system":"14-person, six-week randomized crossover trial.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mg-drenthen2024] Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial (2024). https://pubmed.ncbi.nlm.nih.gov/37922013/ DOI: 10.1007/s00125-023-06029-9","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}