{"id":"39be3b98-8b0e-5080-809b-3d0b09c91aa3","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-collagen-mixture","predicate":"increases","statement":"The mixture increased implant hydroxyproline, a collagen-accumulation measure, without increasing total protein deposition.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"3c4ca536-250b-526c-b77d-3ac674b41d5a","mechanism_event_label":"The study measured a tissue-building outcome, with several ingredients acting together.","subject":{"id":"cfd53b9b-a764-5b01-bcf7-5f2c3b4be5f2","slug":"arginine-hmb-glutamine-mixture","display_name":"Arginine–HMB–glutamine trial mixture","entity_type_key":"chemical_species"},"object":{"id":"aff0ed10-eec6-5574-adf7-3fc5b36a3b95","slug":"implant-collagen-deposition","display_name":"Collagen deposition in subcutaneous PTFE implants","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3c4ca536-250b-526c-b77d-3ac674b41d5a","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-collagen-mixture-event","event_type":"observed_relationship","label":"The study measured a tissue-building outcome, with several ingredients acting together.","description":"The mixture increased implant hydroxyproline, a collagen-accumulation measure, without increasing total protein deposition.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"cfd53b9b-a764-5b01-bcf7-5f2c3b4be5f2","slug":"arginine-hmb-glutamine-mixture","display_name":"Arginine–HMB–glutamine trial mixture","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"aff0ed10-eec6-5574-adf7-3fc5b36a3b95","slug":"implant-collagen-deposition","display_name":"Collagen deposition in subcutaneous PTFE implants","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"35 adults aged at least 70; 14 g arginine, 3 g HMB and 14 g glutamine daily versus isonitrogenous/isocaloric control.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cannot isolate arginine, prove the proline route caused the effect, or establish faster healing of clinical wounds.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Arginine collection; tissue, species, dose and formulation distinctions retained.","comparator":null,"unit":null,"notes":"","entity":{"slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The study measured a tissue-building outcome, with several ingredients acting together.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effect of a specialized amino acid mixture on human collagen deposition. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12192323/ · DOI 10.1097/00000658-200209000-00013","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2d9b78c8-e5b7-59d0-a414-cc4947cfe9e8","evidence_kind":"source_excerpt","locator":"Lines 422-428","start_line":422,"end_line":428,"excerpt":"## arg-collagen-mixture\nThe study measured a tissue-building outcome, with several ingredients acting together.\nThe mixture increased implant hydroxyproline, a collagen-accumulation measure, without increasing total protein deposition.\nModel: 35 adults aged at least 70; 14 g arginine, 3 g HMB and 14 g glutamine daily versus isonitrogenous/isocaloric control.\nLimitations: Cannot isolate arginine, prove the proline route caused the effect, or establish faster healing of clinical wounds.\nEvidence access: Primary abstract\nEffect of a specialized amino acid mixture on human collagen deposition. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12192323/ · DOI 10.1097/00000658-200209000-00013","model_system":"35 adults aged at least 70; 14 g arginine, 3 g HMB and 14 g glutamine daily versus isonitrogenous/isocaloric control.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; primary evidence access stated per claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bb9a67ea-904f-5b8a-93a4-459081212bdd","stable_key":"import-fd37d270-3395-56d6-9f1c-ddda56e606f6","title":"L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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