{"id":"39b18776-67fa-5c65-87cf-e8b57633d24a","stable_key":"63ce713e-6aea-59f6-9896-ca30e010b2ce:l-tyrosine-bacterial-tyramine","predicate":"produces","statement":"Gut bacterial tyrosine decarboxylase accepts tyrosine and also decarboxylates levodopa.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d832ca69-276c-5532-90d8-bd1b4755fa5d","mechanism_event_label":"Microbes can divert the amino acid into a bioactive amine.","subject":{"id":"e8f2d674-296d-5160-9e98-c423f754ff59","slug":"enterococcus-faecalis-tyrosine-decarboxylase","display_name":"Enterococcus faecalis tyrosine decarboxylase","entity_type_key":"protein"},"object":{"id":"db95e69b-dd32-5fd7-8615-62899f42c17e","slug":"tyramine","display_name":"Tyramine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"d832ca69-276c-5532-90d8-bd1b4755fa5d","stable_key":"63ce713e-6aea-59f6-9896-ca30e010b2ce:l-tyrosine-bacterial-tyramine-event","event_type":"observed_relationship","label":"Microbes can divert the amino acid into a bioactive amine.","description":"Gut bacterial tyrosine decarboxylase accepts tyrosine and also decarboxylates levodopa.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e8f2d674-296d-5160-9e98-c423f754ff59","slug":"enterococcus-faecalis-tyrosine-decarboxylase","display_name":"Enterococcus faecalis tyrosine decarboxylase","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"db95e69b-dd32-5fd7-8615-62899f42c17e","slug":"tyramine","display_name":"Tyramine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bcfef85f-831d-5439-ba51-1aef4b090441","slug":"l-tyrosine","display_name":"L-Tyrosine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"6b656ff5-9532-5da4-8eea-8ca163a48649","slug":"pyridoxal-phosphate","display_name":"PLP","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"d2e54a66-7f3c-5bcc-adbe-9f66ad4264f4","slug":"l-dopa","display_name":"L-3,4-Dihydroxyphenylalanine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Gut bacterial enzyme/substrate characterization.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This is bacterial metabolism, distinct from human DDC. Tyramine exposure from food is not equivalent to free tyrosine intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Tyrosine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-tyrosine","display_name":"L-Tyrosine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Microbes can divert the amino acid into a bioactive amine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson's disease. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30659181/ · DOI 10.1038/s41467-019-08294-y","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"da07de6e-9b44-54c2-bb9a-b9651129cd87","evidence_kind":"source_excerpt","locator":"Lines 332-338","start_line":332,"end_line":338,"excerpt":"## l-tyrosine-bacterial-tyramine\nMicrobes can divert the amino acid into a bioactive amine.\nGut bacterial tyrosine decarboxylase accepts tyrosine and also decarboxylates levodopa.\nModel: Gut bacterial enzyme/substrate characterization.\nLimitations: This is bacterial metabolism, distinct from human DDC. Tyramine exposure from food is not equivalent to free tyrosine intake.\nEvidence access: Primary abstract\nGut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson's disease. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30659181/ · DOI 10.1038/s41467-019-08294-y","model_system":"Gut bacterial enzyme/substrate characterization.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"12917df2-c6e0-5b61-850f-dbff6d4b4d30","stable_key":"import-63ce713e-6aea-59f6-9896-ca30e010b2ce","title":"L-Tyrosine: catecholamines, thyroid chemistry, pigment, metabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"7777f4440a8bfb14a04ff73e73392ccc45d8ee89f7853ecbcc0027d6f563b8a0","revision_id":"e1206111-3a75-5809-b8e9-231ff809ff1e","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}