{"id":"398ce2ec-867f-54cf-9371-7cc97d22bf49","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-cochlear-defense","predicate":"preserves","statement":"Ergothioneine reduced cisplatin-associated auditory threshold shifts by about 30 dB in the mouse comparison.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"0e9238d5-dad1-5ff9-908e-9fc41314785a","mechanism_event_label":"Protection extended to an experimental hearing injury.","subject":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"object":{"id":"13d59ef5-487a-5581-b293-70dca6df51d2","slug":"mouse-cisplatin-hearing-response","display_name":"Mouse auditory response during cisplatin exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0e9238d5-dad1-5ff9-908e-9fc41314785a","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-cochlear-defense-event","event_type":"observed_relationship","label":"Protection extended to an experimental hearing injury.","description":"Ergothioneine reduced cisplatin-associated auditory threshold shifts by about 30 dB in the mouse comparison.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"13d59ef5-487a-5581-b293-70dca6df51d2","slug":"mouse-cisplatin-hearing-response","display_name":"Mouse auditory response during cisplatin exposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"95319607-3946-51b3-8235-400ec3223692","slug":"mouse-nfe2l2","display_name":"Mouse Nrf2 / Nfe2l2","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cisplatin-exposed mice; cell experiments examined antioxidant signaling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not establish safe cotreatment in cancer patients or preserved antitumor efficacy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Protection extended to an experimental hearing injury.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The Antioxidant Ergothioneine Alleviates Cisplatin-Induced Hearing Loss Through the Nrf2 Pathway. · 2025 · https://pubmed.ncbi.nlm.nih.gov/38770822/ · DOI 10.1089/ars.2024.0648","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a9b92e3b-e360-5876-8fb5-dd1b08fcb39a","evidence_kind":"source_excerpt","locator":"Lines 408-414","start_line":408,"end_line":414,"excerpt":"## ergothioneine-cochlear-defense\nProtection extended to an experimental hearing injury.\nErgothioneine reduced cisplatin-associated auditory threshold shifts by about 30 dB in the mouse comparison.\nModel: Cisplatin-exposed mice; cell experiments examined antioxidant signaling.\nLimitations: Does not establish safe cotreatment in cancer patients or preserved antitumor efficacy.\nEvidence access: Primary abstract\nThe Antioxidant Ergothioneine Alleviates Cisplatin-Induced Hearing Loss Through the Nrf2 Pathway. · 2025 · https://pubmed.ncbi.nlm.nih.gov/38770822/ · DOI 10.1089/ars.2024.0648","model_system":"Cisplatin-exposed mice; cell experiments examined antioxidant signaling.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2f037d98-f3d0-5dbe-80d8-90b738f130d6","stable_key":"import-59b18080-c560-563d-abc5-bac4ee82a27c","title":"Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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