{"id":"390e0d71-4e3b-5d85-8ab9-0af655493f1d","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-sodium-potassium-salt-stroke-trial","predicate":"combined_salt_substitution_reduces","statement":"The 75% NaCl/25% KCl salt substitute reduced stroke incidence versus ordinary salt in SSaSS (rate ratio 0.86).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"8de05e7c-9d2b-5197-a11c-305961e53305","mechanism_event_label":"Replacing part of sodium chloride with potassium chloride improved a clinical outcome in the studied population.","subject":{"id":"9a56258e-7dda-5b6a-9a14-58c9fe1856c3","slug":"potassium-chloride","display_name":"Potassium chloride","entity_type_key":"chemical_species"},"object":{"id":"9e8b0869-b5af-58ad-95ab-74c850ed9993","slug":"stroke-incidence","display_name":"Stroke incidence","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8de05e7c-9d2b-5197-a11c-305961e53305","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-sodium-potassium-salt-stroke-trial-event","event_type":"observed_intervention","label":"Replacing part of sodium chloride with potassium chloride improved a clinical outcome in the studied population.","description":"The 75% NaCl/25% KCl salt substitute reduced stroke incidence versus ordinary salt in SSaSS (rate ratio 0.86).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f3fe99b8-4e4a-57cd-9a86-3651092c9f6c","slug":"sodium-chloride","display_name":"Sodium chloride","entity_type_key":"chemical_species"},"role":"reduced_component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"cointervention","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"increased_component","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9a56258e-7dda-5b6a-9a14-58c9fe1856c3","slug":"potassium-chloride","display_name":"Potassium chloride","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"9e8b0869-b5af-58ad-95ab-74c850ed9993","slug":"stroke-incidence","display_name":"Stroke incidence","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Combined sodium reduction/potassium increase; not potassium-alone molecular causation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cluster-randomized trial; mean 4.74-year follow-up.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Both sodium and potassium changed, so their effects cannot be separated. Serious kidney disease and potassium-sparing drugs/supplements were excluded; no serial serum-potassium surveillance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Replacing part of sodium chloride with potassium chloride improved a clinical outcome in the studied population.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k-neal2021] Effect of Salt Substitution on Cardiovascular Events and Death (2021). https://pubmed.ncbi.nlm.nih.gov/34459569/ DOI: 10.1056/nejmoa2105675","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Clinical cerebrovascular outcome","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"46b09eff-bfd1-584f-9f04-0d203db3c4bc","evidence_kind":"source_excerpt","locator":"Lines 1697-1707","start_line":1697,"end_line":1707,"excerpt":"### k-sodium-potassium-salt-stroke-trial\nThe 75% NaCl/25% KCl salt substitute reduced stroke incidence versus ordinary salt in SSaSS (rate ratio 0.86).\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Replacing part of sodium chloride with potassium chloride improved a clinical outcome in the studied population.\norganism: Homo sapiens\ntissue_or_cell_type: Clinical cerebrovascular outcome\nexperimental_model: Cluster-randomized trial; mean 4.74-year follow-up.\nlimitations: Both sodium and potassium changed, so their effects cannot be separated. Serious kidney disease and potassium-sparing drugs/supplements were excluded; no serial serum-potassium surveillance.\ncross_nutrient: Combined sodium reduction/potassium increase; not potassium-alone molecular causation.\n[k-neal2021] Effect of Salt Substitution on Cardiovascular Events and Death (2021). https://pubmed.ncbi.nlm.nih.gov/34459569/ DOI: 10.1056/nejmoa2105675","model_system":"Cluster-randomized trial; mean 4.74-year follow-up.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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