{"id":"390da6a6-e053-5073-9b18-6373de716530","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-human-egg-null","predicate":"does_not_induce","statement":"At 10 mM, strontium did not produce calcium oscillations or activation in the tested human oocytes, although TRPV3 expression and responses to TRPV3 agonists were detected.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"a6c69916-64a0-56ab-9f51-4759abd44923","mechanism_event_label":"The mouse result did not transfer to these human eggs.","subject":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"object":{"id":"0c64ab67-d3a7-5179-b5b1-ba4d0167dfbf","slug":"human-strontium-oocyte-activation","display_name":"Human oocyte activation after strontium exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a6c69916-64a0-56ab-9f51-4759abd44923","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-human-egg-null-event","event_type":"observed_relationship","label":"The mouse result did not transfer to these human eggs.","description":"At 10 mM, strontium did not produce calcium oscillations or activation in the tested human oocytes, although TRPV3 expression and responses to TRPV3 agonists were detected.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0c64ab67-d3a7-5179-b5b1-ba4d0167dfbf","slug":"human-strontium-oocyte-activation","display_name":"Human oocyte activation after strontium exposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"35874739-f5cb-538d-8eb0-75365191934c","slug":"trpv3","display_name":"Human TRPV3","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Small human oocyte study, largely in-vitro matured material, with mouse comparisons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited fresh in-vivo-matured human oocytes and no human knockout; channel presence is not proof of strontium permeability.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"The mouse result did not transfer to these human eggs.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Strontium fails to induce Ca2+ release and activation in human oocytes despite the presence of functional TRPV3 channels. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30895246/ · DOI 10.1093/hropen/hoy005","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9b2fae5e-e1f3-5d51-b381-305ccdfe4891","evidence_kind":"source_excerpt","locator":"Lines 398-404","start_line":398,"end_line":404,"excerpt":"## strontium-human-egg-null\nThe mouse result did not transfer to these human eggs.\nAt 10 mM, strontium did not produce calcium oscillations or activation in the tested human oocytes, although TRPV3 expression and responses to TRPV3 agonists were detected.\nModel: Small human oocyte study, largely in-vitro matured material, with mouse comparisons.\nLimitations: Limited fresh in-vivo-matured human oocytes and no human knockout; channel presence is not proof of strontium permeability.\nEvidence access: Primary full text\nStrontium fails to induce Ca2+ release and activation in human oocytes despite the presence of functional TRPV3 channels. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30895246/ · DOI 10.1093/hropen/hoy005","model_system":"Small human oocyte study, largely in-vitro matured material, with mouse comparisons.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"43ef0fe7-eb6c-5346-8381-f7694733b4dc","stable_key":"import-1ff3a29f-ef80-5bff-9300-30b98c60b90d","title":"Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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