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Observational designs cannot separate use that causes psychosis from use that precedes it for other reasons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates.","comparator":null,"unit":null,"notes":"","entity":{"slug":"tetrahydrocannabinol","display_name":"Delta-9-tetrahydrocannabinol / THC","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The heaviest users had about four times the risk, and the risk rose with the amount used.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[thc-p26884547] Meta-analysis of the Association Between the Level of Cannabis Use and Risk of Psychosis. 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Observational designs cannot separate use that causes psychosis from use that precedes it for other reasons.\nexposure: Level of cannabis consumption before psychosis onset\nevidence_span: {\"source_cache\": \"artifacts/thc-research/26884547.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4f62f6a3846a5e753f3268581ec2d6cedb08c6844df6ba9dd32f74bc09947231\", \"start_char\": 0, \"end_char\": 1584, \"text_sha256\": \"4f62f6a3846a5e753f3268581ec2d6cedb08c6844df6ba9dd32f74bc09947231\"}\n[thc-p26884547] Meta-analysis of the Association Between the Level of Cannabis Use and Risk of Psychosis. (2016). https://pubmed.ncbi.nlm.nih.gov/26884547/ DOI: 10.1093/schbul/sbw003","model_system":"Systematic review and meta-analysis of 10 studies and 66,816 individuals","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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