{"id":"38ce15d6-6572-501c-a52e-e2c292936b02","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-mouse-ketones","predicate":"stimulates","statement":"FGF21 stimulated liver ketogenesis and white-adipose lipolysis.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f4e83982-9e47-5835-8eb2-ae9e4fdcd8be","mechanism_event_label":"The endocrine signal altered fuel mobilization.","subject":{"id":"8b01fe3c-a32b-5076-9c61-34d4d35e8b89","slug":"mouse-fgf21","display_name":"Mouse fibroblast growth factor 21 / Fgf21","entity_type_key":"protein"},"object":{"id":"399b71e9-675f-5044-b2f3-7bcda41aaccb","slug":"ketogenesis","display_name":"Ketone-body production","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f4e83982-9e47-5835-8eb2-ae9e4fdcd8be","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-mouse-ketones-event","event_type":"observed_relationship","label":"The endocrine signal altered fuel mobilization.","description":"FGF21 stimulated liver ketogenesis and white-adipose lipolysis.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8b01fe3c-a32b-5076-9c61-34d4d35e8b89","slug":"mouse-fgf21","display_name":"Mouse fibroblast growth factor 21 / Fgf21","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"399b71e9-675f-5044-b2f3-7bcda41aaccb","slug":"ketogenesis","display_name":"Ketone-body production","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"609e2bca-5c38-55d5-a4fc-a65e72f98427","slug":"mouse-adipocyte-lipolysis","display_name":"Mouse adipocyte lipolysis","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Human timing differs; shared pathway labels retain mouse context.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"The endocrine signal altered fuel mobilization.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17550777/ · DOI 10.1016/j.cmet.2007.05.003","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d1ebbf50-6af9-58ca-aeed-c83b88fdc244","evidence_kind":"source_excerpt","locator":"Lines 248-254","start_line":248,"end_line":254,"excerpt":"## fast-mouse-ketones\nThe endocrine signal altered fuel mobilization.\nFGF21 stimulated liver ketogenesis and white-adipose lipolysis.\nModel: Mouse experiments.\nLimitations: Human timing differs; shared pathway labels retain mouse context.\nEvidence access: Primary abstract\nEndocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17550777/ · DOI 10.1016/j.cmet.2007.05.003","model_system":"Mouse experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}