{"id":"3840035e-fa01-5565-802e-ee8473beec53","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-bdh-reaction","predicate":"reversibly_oxidized_to","statement":"BDH1 interconverts D-beta-hydroxybutyrate and acetoacetate using the NAD+/NADH redox pair.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e1f7b56a-738c-5a35-aac4-ff157a4fca1c","mechanism_event_label":"Ketone interconversion connects to niacin-derived redox chemistry.","subject":{"id":"59496369-eea6-5302-a0a3-2dcfa8f2b71a","slug":"d-beta-hydroxybutyrate","display_name":"D-(R)-beta-hydroxybutyrate","entity_type_key":"small_molecule"},"object":{"id":"1b77cb4a-1f79-50e2-b4f0-fd0953cb914e","slug":"acetoacetate","display_name":"Acetoacetate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"e1f7b56a-738c-5a35-aac4-ff157a4fca1c","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-bdh-reaction-event","event_type":"observed_relationship","label":"Ketone interconversion connects to niacin-derived redox chemistry.","description":"BDH1 interconverts D-beta-hydroxybutyrate and acetoacetate using the NAD+/NADH redox pair.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"59496369-eea6-5302-a0a3-2dcfa8f2b71a","slug":"d-beta-hydroxybutyrate","display_name":"D-(R)-beta-hydroxybutyrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1b77cb4a-1f79-50e2-b4f0-fd0953cb914e","slug":"acetoacetate","display_name":"Acetoacetate","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6dff3d80-4bfc-5fc8-b0ab-d2ff426d8df2","slug":"bdh1","display_name":"Human mitochondrial D-beta-hydroxybutyrate dehydrogenase / BDH1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"283ed24b-06a1-50aa-9281-df3bac6ce37e","slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"9fbf2e03-16a9-5ca7-965c-0bfc07ca24da","slug":"nadh","display_name":"NADH","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Reactome curated reaction and its primary-study attribution","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Curated human mitochondrial reaction R-HSA-73920; cites human-heart BDH1 work.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Reversible reaction; redox state and compartment determine net direction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"Ketone interconversion connects to niacin-derived redox chemistry.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"BDH1: D-beta-hydroxybutyrate + NAD+ ⇌ acetoacetate + NADH + H+ · 2003 · https://reactome.org/content/detail/R-HSA-73920","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"62ba92b1-9bad-5630-9ca8-a53105f2dee2","evidence_kind":"source_excerpt","locator":"Lines 128-134","start_line":128,"end_line":134,"excerpt":"## fast-bdh-reaction\nKetone interconversion connects to niacin-derived redox chemistry.\nBDH1 interconverts D-beta-hydroxybutyrate and acetoacetate using the NAD+/NADH redox pair.\nModel: Curated human mitochondrial reaction R-HSA-73920; cites human-heart BDH1 work.\nLimitations: Reversible reaction; redox state and compartment determine net direction.\nEvidence access: Reactome curated reaction and its primary-study attribution\nBDH1: D-beta-hydroxybutyrate + NAD+ ⇌ acetoacetate + NADH + H+ · 2003 · https://reactome.org/content/detail/R-HSA-73920","model_system":"Curated human mitochondrial reaction R-HSA-73920; cites human-heart BDH1 work.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}