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The molecular route from the endosomal lumen to cytosol remains unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chromium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human proteins in vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Acidification helps release chromium from its carrier, with different behavior at the two sites.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chromium-p31669693] Release of trivalent chromium from serum transferrin is sufficiently rapid to be physiologically relevant. 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The molecular route from the endosomal lumen to cytosol remains unresolved.\nexposure: pH 4.5 and 5.5; weak/tight binding sites; biological chelators and soluble transferrin receptor\nevidence_span: {\"source_cache\": \"artifacts/chromium-research/31669693.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"bdb962ff7838d36dfbc2cd2df4eed4e07c81ebd824c6e95096c5d7069ec32835\", \"start_char\": 0, \"end_char\": 1635, \"text_sha256\": \"bdb962ff7838d36dfbc2cd2df4eed4e07c81ebd824c6e95096c5d7069ec32835\"}\n[chromium-p31669693] Release of trivalent chromium from serum transferrin is sufficiently rapid to be physiologically relevant. 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