{"id":"38068772-193f-531f-88ac-af049b4dce9c","stable_key":"96d9034a-2550-5f3c-b767-1767c982533c:plus-lariciresinol-raises-heme-oxygenase-1","predicate":"increases","statement":"(+)-Lariciresinol increased heme oxygenase 1 at both transcriptional and translational levels, alongside the rise in Nrf2.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"203838a9-844e-5732-85e2-3ec0bc626567","mechanism_event_label":"(+)-Lariciresinol increased heme oxygenase 1 at both transcriptional and translational levels, alongside the rise in Nrf2.","subject":{"id":"09e8fc4d-e8f7-569b-a427-4c271f523a30","slug":"plus-lariciresinol","display_name":"(+)-Lariciresinol","entity_type_key":"small_molecule"},"object":{"id":"26298c7c-5265-5bf5-a435-e0fa98a3ac10","slug":"hmox1","display_name":"Human heme oxygenase 1 / HMOX1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"203838a9-844e-5732-85e2-3ec0bc626567","stable_key":"96d9034a-2550-5f3c-b767-1767c982533c:plus-lariciresinol-raises-heme-oxygenase-1-event","event_type":"observed_relationship","label":"(+)-Lariciresinol increased heme oxygenase 1 at both transcriptional and translational levels, alongside the rise in Nrf2.","description":"(+)-Lariciresinol increased heme oxygenase 1 at both transcriptional and translational levels, alongside the rise in Nrf2.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"09e8fc4d-e8f7-569b-a427-4c271f523a30","slug":"plus-lariciresinol","display_name":"(+)-Lariciresinol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"26298c7c-5265-5bf5-a435-e0fa98a3ac10","slug":"hmox1","display_name":"Human heme oxygenase 1 / HMOX1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"dc472dd3-d383-567a-ab37-a9ec4e112df4","slug":"nfe2l2","display_name":"Human Nrf2 / NFE2L2","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"RAW 264.7 murine macrophages","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"(+)-Lariciresinol","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The abstract reports the rise in HO-1 as corresponding to the rise in Nrf2; the causal test by Nrf2 inhibition is described in the full text and was not read here.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"RAW 264.7 murine macrophages","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"(+)-Lariciresinol increased heme oxygenase 1 at both transcriptional and translational levels, alongside the rise in Nrf2.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Antioxidant efficacy and the upregulation of Nrf2-mediated HO-1 expression by (+)-lariciresinol, a lignan isolated from Rubia philippinensis, through the activation of p38. (2017). https://pubmed.ncbi.nlm.nih.gov/28378774/ DOI: 10.1038/srep46035","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Heme oxygenase 1 expression","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e30c2f08-3299-5762-a7db-fee9063012aa","evidence_kind":"source_excerpt","locator":"Lines 44-53","start_line":44,"end_line":53,"excerpt":"## plus-lariciresinol-raises-heme-oxygenase-1\n(+)-Lariciresinol increased heme oxygenase 1 at both transcriptional and translational levels, alongside the rise in Nrf2.\nModel/species: RAW 264.7 murine macrophages\nTissue/system: Heme oxygenase 1 expression\nExposure: (+)-Lariciresinol\nRoute: In vitro\nDuration: Not stated here\nLimits: The abstract reports the rise in HO-1 as corresponding to the rise in Nrf2; the causal test by Nrf2 inhibition is described in the full text and was not read here.\nPrimary reference: Antioxidant efficacy and the upregulation of Nrf2-mediated HO-1 expression by (+)-lariciresinol, a lignan isolated from Rubia philippinensis, through the activation of p38. (2017). https://pubmed.ncbi.nlm.nih.gov/28378774/ DOI: 10.1038/srep46035\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"48c58761-0291-5bad-a926-75e904b2d802","stable_key":"import-96d9034a-2550-5f3c-b767-1767c982533c","title":"Lariciresinol: five molecules under one name, and the mechanisms each one carries (2026-09-22)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twelve primary studies, every abstract read and all DOIs cross-checked against live PubMed metadata. Mechanism edges only, with no conclusion or claim of benefit recorded. Three author clusters account for eight of the twelve and carry shared laboratory keys. Study-specific concentrations, negative findings and limitations retained. Not publisher full text.","file_path":"","sha256":"6bf0015b7ff727b7a80d693dd18ffdd227d0e16ae45d9e85a5f81fa733edd3a4","revision_id":"219d9b0c-1a71-5e27-8d6c-7b3e77a594c6","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}