{"id":"37cc6993-5646-5e6e-aafe-6eff5a70750e","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-tat1-transport","predicate":"transports","statement":"Human TAT1 expressed in Xenopus oocytes transported tryptophan, tyrosine, phenylalanine and L-DOPA independently of sodium.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"03e06bf3-d4f4-535a-9779-730fd2fbf96b","mechanism_event_label":"Tryptophan also has an aromatic-amino-acid transport route.","subject":{"id":"69cdf826-b328-595e-b377-b549d6188970","slug":"slc16a10","display_name":"Human TAT1 / SLC16A10","entity_type_key":"protein"},"object":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"03e06bf3-d4f4-535a-9779-730fd2fbf96b","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-tat1-transport-event","event_type":"observed_relationship","label":"Tryptophan also has an aromatic-amino-acid transport route.","description":"Human TAT1 expressed in Xenopus oocytes transported tryptophan, tyrosine, phenylalanine and L-DOPA independently of sodium.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"69cdf826-b328-595e-b377-b549d6188970","slug":"slc16a10","display_name":"Human TAT1 / SLC16A10","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bcfef85f-831d-5439-ba51-1aef4b090441","slug":"l-tyrosine","display_name":"L-Tyrosine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"190407ad-0219-54b5-b05f-7c75f3895ca6","slug":"l-phenylalanine","display_name":"L-Phenylalanine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human cloned transporter; expression strongest in kidney and intestine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The paper proposes disease relevance; it does not establish TAT1 defects as the cause of blue diaper syndrome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Tryptophan also has an aromatic-amino-acid transport route.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11827462/ · DOI 10.1006/geno.2001.6678","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_effect","value_text":"raises","comparator":null,"unit":null,"notes":"An oocyte transport measurement, which reports the cell interior rising. TAT1's role at the basolateral membrane is efflux, which this record does not measure.","entity":null},{"dimension":"transport_pool","value_text":"the expressing cell","comparator":null,"unit":null,"notes":"An oocyte transport measurement, which reports the cell interior rising. TAT1's role at the basolateral membrane is efflux, which this record does not measure.","entity":null}],"evidence":[{"id":"f03a7cc6-b7c3-5070-a39e-b581c961ce64","evidence_kind":"source_excerpt","locator":"Lines 50-56","start_line":50,"end_line":56,"excerpt":"## tryptophan-tat1-transport\nTryptophan also has an aromatic-amino-acid transport route.\nHuman TAT1 expressed in Xenopus oocytes transported tryptophan, tyrosine, phenylalanine and L-DOPA independently of sodium.\nModel: Human cloned transporter; expression strongest in kidney and intestine.\nLimitations: The paper proposes disease relevance; it does not establish TAT1 defects as the cause of blue diaper syndrome.\nEvidence access: Primary abstract\nThe human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11827462/ · DOI 10.1006/geno.2001.6678","model_system":"Human cloned transporter; expression strongest in kidney and intestine.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73f9d3e7-fdc9-5418-8f3c-f4ef145f6efa","stable_key":"import-584c58f5-ab9f-53f3-97a9-55783db943b0","title":"Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"7dfd20063b91900cb5c6ad675e3e675b7e25ef0fb8304eabac6f263cc5518284","revision_id":"bfafd789-fdf5-521f-bd28-c662e01ec1ea","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}