{"id":"37bc7dbb-3789-55fc-9506-d2b907c22802","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:ca-ip3-mobilizes-store","predicate":"promotes","statement":"Applied IP3 releases calcium from a nonmitochondrial intracellular store in permeabilized pancreatic acinar cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cfc34d66-a76f-5359-9496-0eda370f960b","mechanism_event_label":"IP3 releases stored calcium inside acinar cells.","subject":{"id":"7005bbc2-d4b5-5903-b776-94dd2288d35f","slug":"ip3","display_name":"IP3","entity_type_key":"small_molecule"},"object":{"id":"092bae47-1801-5c38-aca4-9da2e7125458","slug":"er-calcium-release","display_name":"ER calcium release","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cfc34d66-a76f-5359-9496-0eda370f960b","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:ca-ip3-mobilizes-store-event","event_type":"mechanism","label":"IP3 releases stored calcium inside acinar cells.","description":"Applied IP3 releases calcium from a nonmitochondrial intracellular store in permeabilized pancreatic acinar cells.","status":"provisional","compartment":{"slug":"nonmitochondrial-intracellular-store","display_name":"Experimentally identified nonmitochondrial intracellular store"},"participants":[{"entity":{"id":"7005bbc2-d4b5-5903-b776-94dd2288d35f","slug":"ip3","display_name":"IP3","entity_type_key":"small_molecule"},"role":"second_messenger","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"transported_substrate","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"092bae47-1801-5c38-aca4-9da2e7125458","slug":"er-calcium-release","display_name":"ER calcium release","entity_type_key":"cellular_process"},"role":"process","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7d33a7f3-a029-5c08-adf6-9ccc99da3089","slug":"nonmitochondrial-intracellular-store","display_name":"Experimentally identified nonmitochondrial intracellular store","entity_type_key":"organelle"},"role":"experimental_location","stoichiometry":null,"state_label":"","sequence_order":3,"notes":"Study location; presence here is not a separate transport or causal claim."},{"entity":{"id":"bc9ed3a1-38d5-5bc3-b2a5-9f9f7633660b","slug":"cytosol","display_name":"Cytosol","entity_type_key":"organelle"},"role":"experimental_location","stoichiometry":null,"state_label":"","sequence_order":4,"notes":"Study location; presence here is not a separate transport or causal claim."}]},"contexts":[{"dimension":"compartment_description","value_text":"Nonmitochondrial intracellular store to cytosol","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Permeabilized rat pancreatic acinar cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Permeabilized-cell application; receptor isoform and dietary status were not established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"IP3 releases stored calcium inside acinar cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ca-streb1983] Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate (1983). https://pubmed.ncbi.nlm.nih.gov/6605482/ DOI: 10.1038/306067a0","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"research_relationship_category","value_text":"mechanism","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Pancreatic acinar cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_or_reaction_direction","value_text":"Intracellular store to cytosol","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c7da4cd4-c12f-5306-8041-904187f96836","evidence_kind":"source_excerpt","locator":"Lines 464-476","start_line":464,"end_line":476,"excerpt":"### ca-ip3-mobilizes-store\nApplied IP3 releases calcium from a nonmitochondrial intracellular store in permeabilized pancreatic acinar cells.\nCondition category: normal\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: IP3 releases stored calcium inside acinar cells.\norganism: Rattus norvegicus\ntissue_or_cell_type: Pancreatic acinar cells\nexperimental_model: Permeabilized rat pancreatic acinar cells\nlimitations: Permeabilized-cell application; receptor isoform and dietary status were not established.\nresearch_relationship_category: mechanism\ntransport_or_reaction_direction: Intracellular store to cytosol\ncompartment_description: Nonmitochondrial intracellular store to cytosol\n[ca-streb1983] Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate (1983). https://pubmed.ncbi.nlm.nih.gov/6605482/ DOI: 10.1038/306067a0","model_system":"Permeabilized rat pancreatic acinar cells","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ca-streb1983] Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate (1983). https://pubmed.ncbi.nlm.nih.gov/6605482/ DOI: 10.1038/306067a0","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3c083fa0-59c6-50e9-af42-678d0e3c1006","stable_key":"import-434e1e27-eb90-583a-956b-62472726ffba","title":"Calcium: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"965c934d6b147f2b62f8d45ce6d7a87681a600bfe5c46a585b4704889afd3fc1","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}