{"id":"37a3d585-4181-59ef-af07-e1dd3d3ebfd6","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-ovx-boron-magnesium","predicate":"with_magnesium_increases","statement":"Magnesium, boron and their combination improved measured bone endpoints after ovariectomy in rats, with the combined intervention reported to outperform the individual interventions.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"ed2a508f-02bb-5c62-acd4-e3d5e2f1256d","mechanism_event_label":"The combination performed better in this rat model of hormone-related bone loss.","subject":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"object":{"id":"8967827f-50c6-55f2-9c8a-dfc05fd70a77","slug":"bone-mineral-density","display_name":"Bone mineral density","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ed2a508f-02bb-5c62-acd4-e3d5e2f1256d","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-ovx-boron-magnesium-event","event_type":"observed_intervention","label":"The combination performed better in this rat model of hormone-related bone loss.","description":"Magnesium, boron and their combination improved measured bone endpoints after ovariectomy in rats, with the combined intervention reported to outperform the individual interventions.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"co_exposure","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8967827f-50c6-55f2-9c8a-dfc05fd70a77","slug":"bone-mineral-density","display_name":"Bone mineral density","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/41075129.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d3cf6234f51fd5e8a999607442cd1c8abcc1fe0781369b54797661f18561fbf3\", \"start_char\": 0, \"end_char\": 1591, \"text_sha256\": \"d3cf6234f51fd5e8a999607442cd1c8abcc1fe0781369b54797661f18561fbf3\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Five-group ovariectomy experiment; 30 rats","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Sham, ovariectomy, ovariectomy plus magnesium, boron or both; six rats/group","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small animal experiment. Combination benefit does not by itself prove pharmacological synergy or efficacy in human osteoporosis. Doses are not specified in the indexed abstract used here.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Female rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The combination performed better in this rat model of hormone-related bone loss.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p41075129] Combined Supplementation OF Magnesium AND Boron Ameliorate Menopause-Associated Osteogenic Disturbances in Ovariectomized Rats. (2026). https://pubmed.ncbi.nlm.nih.gov/41075129/ DOI: 10.1007/s12011-025-04870-0","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Bone density and mineral/endocrine endpoints","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"298e72c3-c67a-56f5-a152-cb1c969c6149","evidence_kind":"source_excerpt","locator":"Lines 924-935","start_line":924,"end_line":935,"excerpt":"### boron-ovx-boron-magnesium\nMagnesium, boron and their combination improved measured bone endpoints after ovariectomy in rats, with the combined intervention reported to outperform the individual interventions.\nCondition category: normal\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The combination performed better in this rat model of hormone-related bone loss.\norganism: Female rat\ntissue_or_cell_type: Bone density and mineral/endocrine endpoints\nexperimental_model: Five-group ovariectomy experiment; 30 rats\nlimitations: Small animal experiment. Combination benefit does not by itself prove pharmacological synergy or efficacy in human osteoporosis. Doses are not specified in the indexed abstract used here.\nexposure: Sham, ovariectomy, ovariectomy plus magnesium, boron or both; six rats/group\nevidence_span: {\"source_cache\": \"artifacts/boron-research/41075129.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d3cf6234f51fd5e8a999607442cd1c8abcc1fe0781369b54797661f18561fbf3\", \"start_char\": 0, \"end_char\": 1591, \"text_sha256\": \"d3cf6234f51fd5e8a999607442cd1c8abcc1fe0781369b54797661f18561fbf3\"}\n[boron-p41075129] Combined Supplementation OF Magnesium AND Boron Ameliorate Menopause-Associated Osteogenic Disturbances in Ovariectomized Rats. 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