{"id":"377979cb-18d6-55c4-908e-322d20c26435","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-human-small-hepatic-positive","predicate":"reduces","statement":"In eight patients given 50 mg vanadyl sulfate twice daily for four weeks, fasting glucose and hepatic glucose output during insulin infusion decreased, without significant whole-body glucose-uptake improvement.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9edb36f6-7ee9-5f7f-88a5-80e7dcfe892e","mechanism_event_label":"Another small study found a liver-associated effect rather than broad uptake improvement.","subject":{"id":"68c1e8ab-2afe-5c6e-bae1-45b9bb505795","slug":"vanadyl-sulfate","display_name":"Vanadyl sulfate","entity_type_key":"chemical_species"},"object":{"id":"ab0f1906-3475-5080-be99-dc7110347520","slug":"human-four-week-vanadyl-hepatic-output","display_name":"Insulin-suppressed hepatic glucose output after four weeks of vanadyl","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9edb36f6-7ee9-5f7f-88a5-80e7dcfe892e","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-human-small-hepatic-positive-event","event_type":"observed_relationship","label":"Another small study found a liver-associated effect rather than broad uptake improvement.","description":"In eight patients given 50 mg vanadyl sulfate twice daily for four weeks, fasting glucose and hepatic glucose output during insulin infusion decreased, without significant whole-body glucose-uptake improvement.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"68c1e8ab-2afe-5c6e-bae1-45b9bb505795","slug":"vanadyl-sulfate","display_name":"Vanadyl sulfate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ab0f1906-3475-5080-be99-dc7110347520","slug":"human-four-week-vanadyl-hepatic-output","display_name":"Insulin-suppressed hepatic glucose output after four weeks of vanadyl","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c5cbad45-22c6-594b-ab6b-71880dab1b24","slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Single-blind sequential study; six patients continued to a subsequent placebo phase.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Fixed treatment order and persistence into placebo complicate causal inference; six of eight had early gastrointestinal effects.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vanadium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Another small study found a liver-associated effect rather than broad uptake improvement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8781301/ · DOI 10.1016/s0026-0495(96)90013-x","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"43cae0e7-4d3e-5780-abfb-f028bc66a9c4","evidence_kind":"source_excerpt","locator":"Lines 438-444","start_line":438,"end_line":444,"excerpt":"## vanadium-human-small-hepatic-positive\nAnother small study found a liver-associated effect rather than broad uptake improvement.\nIn eight patients given 50 mg vanadyl sulfate twice daily for four weeks, fasting glucose and hepatic glucose output during insulin infusion decreased, without significant whole-body glucose-uptake improvement.\nModel: Single-blind sequential study; six patients continued to a subsequent placebo phase.\nLimitations: Fixed treatment order and persistence into placebo complicate causal inference; six of eight had early gastrointestinal effects.\nEvidence access: Primary abstract\nEffects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8781301/ · DOI 10.1016/s0026-0495(96)90013-x","model_system":"Single-blind sequential study; six patients continued to a subsequent placebo phase.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e4d5d0ba-529b-540f-96ed-e719d116ccfd","stable_key":"import-335be270-ea4a-5c8e-ad04-964fd22a439e","title":"Vanadium: speciation, phosphate-sensitive enzymes and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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