{"id":"37500475-73ed-55ba-b617-c934e1f017ab","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-body-sodium-marker-limit","predicate":"alone_poorly_predicts","statement":"Serum sodium correlated only partly or poorly with the isolated body-composition ratios, including exchangeable sodium/body weight.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cab8c381-28c8-5ff6-a7a1-0c4bc62b17c9","mechanism_event_label":"A low blood sodium result does not, by itself, identify a dietary sodium shortage.","subject":{"id":"7de65b91-9cce-5919-b67d-28d238377e72","slug":"total-exchangeable-sodium","display_name":"Total exchangeable body sodium","entity_type_key":"cellular_process"},"object":{"id":"da7ca55c-2632-5eb7-b91c-94885c90d27e","slug":"plasma-sodium-concentration","display_name":"Plasma or serum sodium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cab8c381-28c8-5ff6-a7a1-0c4bc62b17c9","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-body-sodium-marker-limit-event","event_type":"observed_intervention","label":"A low blood sodium result does not, by itself, identify a dietary sodium shortage.","description":"Serum sodium correlated only partly or poorly with the isolated body-composition ratios, including exchangeable sodium/body weight.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7de65b91-9cce-5919-b67d-28d238377e72","slug":"total-exchangeable-sodium","display_name":"Total exchangeable body sodium","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"da7ca55c-2632-5eb7-b91c-94885c90d27e","slug":"plasma-sodium-concentration","display_name":"Plasma or serum sodium concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/sodium-research/13575523.fulltext.txt\", \"locator\": \"Exact primary full-text span; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"ee58d9f6c640fec095876c15e7ddf6fe8bf539cb972c74841db02d2640eebbe2\", \"start_char\": 54337, \"end_char\": 56036, \"text_sha256\": \"29b3a155f7b33a8b86aa9e30182063d71f5af3c60910a237794c1310094a4c39\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Simultaneous isotope-dilution and serum measurements, including serial observations","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Observed variation in body composition","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Historical observational regression; serum-water sodium and exchangeable pools are not interchangeable with current clinical plasma measurements or all body sodium. Not an individual correction calculator.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sodium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sodium","display_name":"Sodium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human patients with chronic illnesses","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A low blood sodium result does not, by itself, identify a dietary sodium shortage.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sodium-p13575523] Interrelations between serum sodium concentration, serum osmolarity and total exchangeable sodium, total exchangeable potassium and total body water. (1958). https://pubmed.ncbi.nlm.nih.gov/13575523/ DOI: 10.1172/jci103712","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole-body water and exchangeable cations","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ad0a6eb8-d547-5ca1-8fc1-176aea5266e8","evidence_kind":"source_excerpt","locator":"Lines 278-289","start_line":278,"end_line":289,"excerpt":"### sodium-body-sodium-marker-limit\nSerum sodium correlated only partly or poorly with the isolated body-composition ratios, including exchangeable sodium/body weight.\nCondition category: normal\nnutrient_topic: Sodium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A low blood sodium result does not, by itself, identify a dietary sodium shortage.\norganism: Human patients with chronic illnesses\ntissue_or_cell_type: Whole-body water and exchangeable cations\nexperimental_model: Simultaneous isotope-dilution and serum measurements, including serial observations\nlimitations: Historical observational regression; serum-water sodium and exchangeable pools are not interchangeable with current clinical plasma measurements or all body sodium. Not an individual correction calculator.\nexposure: Observed variation in body composition\nevidence_span: {\"source_cache\": \"artifacts/sodium-research/13575523.fulltext.txt\", \"locator\": \"Exact primary full-text span; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"ee58d9f6c640fec095876c15e7ddf6fe8bf539cb972c74841db02d2640eebbe2\", \"start_char\": 54337, \"end_char\": 56036, \"text_sha256\": \"29b3a155f7b33a8b86aa9e30182063d71f5af3c60910a237794c1310094a4c39\"}\n[sodium-p13575523] Interrelations between serum sodium concentration, serum osmolarity and total exchangeable sodium, total exchangeable potassium and total body water. (1958). https://pubmed.ncbi.nlm.nih.gov/13575523/ DOI: 10.1172/jci103712","model_system":"Simultaneous isotope-dilution and serum measurements, including serial observations","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [sodium-p13575523] Interrelations between serum sodium concentration, serum osmolarity and total exchangeable sodium, total exchangeable potassium and total body water. (1958). https://pubmed.ncbi.nlm.nih.gov/13575523/ DOI: 10.1172/jci103712","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c260cd7b-beb0-5113-a198-69ec8fd4492c","stable_key":"import-195e8b84-ca5a-591a-a045-c55c53c8a01c","title":"Sodium: gradients, nutrient transport, fluid regulation and loss states (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"684f65cf0661c18395831ade4b02bb24d5e66c568f0d00a3471600eaf5d4d1c6","revision_id":"39866f04-3052-5f59-bd95-6806c5490875","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}