{"id":"37409eca-993c-5d58-ba3c-b051a128d0fa","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-citrinin-iron-rescue-failure","predicate":"fails_to_prevent_tested","statement":"Deferoxamine pretreatment prevented iron-mediated lipid peroxidation but did not protect rat tubules from citrinin-induced death.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"ad7135e8-471f-5fe6-b724-6db08b56fe85","mechanism_event_label":"Blocking one injury marker did not rescue the cells.","subject":{"id":"279d00c2-a6a3-5943-8d5d-a7eed68e1041","slug":"deferoxamine","display_name":"Deferoxamine","entity_type_key":"drug"},"object":{"id":"4cf868c0-2ae6-5861-ab6d-e6b0f64e9319","slug":"rat-citrinin-proximal-tubule-death","display_name":"Rat renal proximal-tubule death after citrinin exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ad7135e8-471f-5fe6-b724-6db08b56fe85","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-citrinin-iron-rescue-failure-event","event_type":"observed_relationship","label":"Blocking one injury marker did not rescue the cells.","description":"Deferoxamine pretreatment prevented iron-mediated lipid peroxidation but did not protect rat tubules from citrinin-induced death.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"279d00c2-a6a3-5943-8d5d-a7eed68e1041","slug":"deferoxamine","display_name":"Deferoxamine","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4cf868c0-2ae6-5861-ab6d-e6b0f64e9319","slug":"rat-citrinin-proximal-tubule-death","display_name":"Rat renal proximal-tubule death after citrinin exposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"41817c29-526e-5b62-8db3-9553d316ea84","slug":"citrinin","display_name":"Citrinin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"59d6d1cd-df32-5b58-b950-3188bc7b95d6","slug":"iron-ii","display_name":"Ferrous iron","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat proximal-tubule suspensions; 1 mM deferoxamine pretreatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not exclude every oxidative mechanism or establish ferroptosis; distinguishes marker suppression from survival rescue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Blocking one injury marker did not rescue the cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[1853344] The role of altered mitochondrial function in citrinin-induced toxicity to rat renal proximal tubule suspensions. · 1991 · https://pubmed.ncbi.nlm.nih.gov/1853344/ · DOI 10.1016/0041-008x(91)90008-3","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"886b9e0f-25d9-5f3e-aab3-0599cf718245","evidence_kind":"source_excerpt","locator":"Lines 324-330","start_line":324,"end_line":330,"excerpt":"## red-yeast-rice-citrinin-iron-rescue-failure\nBlocking one injury marker did not rescue the cells.\nDeferoxamine pretreatment prevented iron-mediated lipid peroxidation but did not protect rat tubules from citrinin-induced death.\nModel: Rat proximal-tubule suspensions; 1 mM deferoxamine pretreatment.\nLimitations: Does not exclude every oxidative mechanism or establish ferroptosis; distinguishes marker suppression from survival rescue.\nEvidence access: Primary abstract\n[1853344] The role of altered mitochondrial function in citrinin-induced toxicity to rat renal proximal tubule suspensions. · 1991 · https://pubmed.ncbi.nlm.nih.gov/1853344/ · DOI 10.1016/0041-008x(91)90008-3","model_system":"Rat proximal-tubule suspensions; 1 mM deferoxamine pretreatment.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"261a12bc-3d00-52a4-a5ec-70e174390596","stable_key":"import-4910e17b-aaec-52cd-b9e5-caca85d817ee","title":"Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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