{"id":"372ea3cc-41aa-59c4-ae38-5a2b7fdb6f04","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-measles-clinical-endpoint","predicate":"reduces_in_trial","statement":"Vitamin A reduced the combined risk of death or major complications during severe-measles hospitalization in the trial.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"16406b8e-9824-55b9-bfee-0d4887f2ae0c","mechanism_event_label":"A clinical benefit was demonstrated in a defined illness setting.","subject":{"id":"62e3f5bd-503b-5ea8-b102-966aa3b7319c","slug":"retinyl-palmitate","display_name":"All-trans-retinyl palmitate","entity_type_key":"small_molecule"},"object":{"id":"05ef09a4-91d8-5091-bf70-c57b1c681075","slug":"measles-major-complications","display_name":"Major complications or death during measles hospitalization","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"16406b8e-9824-55b9-bfee-0d4887f2ae0c","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-measles-clinical-endpoint-event","event_type":"observed_intervention","label":"A clinical benefit was demonstrated in a defined illness setting.","description":"Vitamin A reduced the combined risk of death or major complications during severe-measles hospitalization in the trial.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"148c57d8-c658-5769-89e8-1194cef2a782","slug":"retinol","display_name":"All-trans-retinol","entity_type_key":"small_molecule"},"role":"low_baseline_biomarker","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"62e3f5bd-503b-5ea8-b102-966aa3b7319c","slug":"retinyl-palmitate","display_name":"All-trans-retinyl palmitate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"05ef09a4-91d8-5091-bf70-c57b1c681075","slug":"measles-major-complications","display_name":"Major complications or death during measles hospitalization","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"189 hospitalized children; randomized trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No specific immune pathway was proven as mediator; not evidence for preventing all infections or replacing vaccination.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A clinical benefit was demonstrated in a defined illness setting.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[va-hussey1990] A randomized, controlled trial of vitamin A in children with severe measles (1990). https://pubmed.ncbi.nlm.nih.gov/2194128/ DOI: 10.1056/nejm199007193230304","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Clinical outcome","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b8f20c63-5ede-551e-a5a2-e3454a58f794","evidence_kind":"source_excerpt","locator":"Lines 1707-1716","start_line":1707,"end_line":1716,"excerpt":"### va-measles-clinical-endpoint\nVitamin A reduced the combined risk of death or major complications during severe-measles hospitalization in the trial.\nCondition category: normal\nnutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A clinical benefit was demonstrated in a defined illness setting.\norganism: Homo sapiens\ntissue_or_cell_type: Clinical outcome\nexperimental_model: 189 hospitalized children; randomized trial.\nlimitations: No specific immune pathway was proven as mediator; not evidence for preventing all infections or replacing vaccination.\n[va-hussey1990] A randomized, controlled trial of vitamin A in children with severe measles (1990). https://pubmed.ncbi.nlm.nih.gov/2194128/ DOI: 10.1056/nejm199007193230304","model_system":"189 hospitalized children; randomized trial.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [va-hussey1990] A randomized, controlled trial of vitamin A in children with severe measles (1990). https://pubmed.ncbi.nlm.nih.gov/2194128/ DOI: 10.1056/nejm199007193230304","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0c5474e2-be48-547b-b287-9c07a59c9ff1","stable_key":"import-dff9f743-3766-5f20-a71e-d6d2bd5bfb6f","title":"Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b217224b262abbd77d6a0c8c9beefff9c022fae4d31e2a5273915d769b9a6546","revision_id":"61008909-871f-575c-b5e2-21542689ea3c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}