{"id":"372b06fe-2171-5ca8-89ad-cf5a82ea56fe","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-human-geraldol-exposure","predicate":"produces_circulating_metabolite","statement":"Geraldol was measured after oral fisetin in the human crossover study; its exposure relative to parent differed between formulations.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"44c8ec46-3e7f-5d8c-b4e9-ec5159696f41","mechanism_event_label":"Human measurements confirm that parent exposure alone is incomplete.","subject":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"object":{"id":"9fdb2610-ab87-5de2-9658-ed83bc42b3fc","slug":"geraldol","display_name":"Geraldol / 3-prime-O-methylfisetin","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"44c8ec46-3e7f-5d8c-b4e9-ec5159696f41","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-human-geraldol-exposure-event","event_type":"observed_relationship","label":"Human measurements confirm that parent exposure alone is incomplete.","description":"Geraldol was measured after oral fisetin in the human crossover study; its exposure relative to parent differed between formulations.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9fdb2610-ab87-5de2-9658-ed83bc42b3fc","slug":"geraldol","display_name":"Geraldol / 3-prime-O-methylfisetin","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"97c4a967-d7f4-57a4-8db1-bc5974090dd3","slug":"human-plasma-unconjugated-fisetin","display_name":"Human plasma unconjugated fisetin exposure","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e458fd5b-1e3f-56af-831d-ebcb9b1f1ecc","slug":"fisetin-ff20-formulation","display_name":"FF-20 fisetin micelle/fenugreek-galactomannan formulation","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Unconjugated parent and geraldol LC-MS/MS measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a complete metabolite balance; altered ratios do not identify the causal absorption or metabolism step.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Human measurements confirm that parent exposure alone is incomplete.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36304817/ · DOI 10.1017/jns.2022.72","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"f3f771b5-6350-5f8f-8a7c-c09ea1cda198","evidence_kind":"source_excerpt","locator":"Lines 80-86","start_line":80,"end_line":86,"excerpt":"## fisetin-human-geraldol-exposure\nHuman measurements confirm that parent exposure alone is incomplete.\nGeraldol was measured after oral fisetin in the human crossover study; its exposure relative to parent differed between formulations.\nModel: Unconjugated parent and geraldol LC-MS/MS measurements.\nLimitations: Not a complete metabolite balance; altered ratios do not identify the causal absorption or metabolism step.\nEvidence access: Primary abstract\nEnhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36304817/ · DOI 10.1017/jns.2022.72","model_system":"Unconjugated parent and geraldol LC-MS/MS measurements.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1108bfff-6504-5152-a51f-ff3d7c27c282","stable_key":"import-74ef5bba-ee14-531c-b1bf-d1f297c56bb6","title":"Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c30e0764cd34bd062cfcbfaf32357ef29dfda30e7d4153c545178140f5054e09","revision_id":"40ff52c0-f4b9-5820-8abb-ff002c6364a4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}