{"id":"37247315-a7d6-5124-81c9-08bc3e36d257","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-imp-p38-p62","predicate":"phosphorylates_tested","statement":"The 2018 study linked imidazole-propionate-activated p38-gamma to p62 phosphorylation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"18225ed4-849e-5370-b2c6-cbbe2728a14d","mechanism_event_label":"A kinase relays the microbial-metabolite signal to an adaptor protein.","subject":{"id":"5e1ea5b4-beb1-530a-a52a-3acf1b5c6d15","slug":"imp-study-p38gamma-assay","display_name":"p38-gamma assay protein in the 2018 ImP study; species unresolved in accessed abstract","entity_type_key":"protein"},"object":{"id":"556e7f38-1cfa-5f34-ac1c-133fcc378027","slug":"imp-study-p62-assay","display_name":"p62 assay protein in the 2018 ImP study; species unresolved in accessed abstract","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"18225ed4-849e-5370-b2c6-cbbe2728a14d","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-imp-p38-p62-event","event_type":"observed_relationship","label":"A kinase relays the microbial-metabolite signal to an adaptor protein.","description":"The 2018 study linked imidazole-propionate-activated p38-gamma to p62 phosphorylation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5e1ea5b4-beb1-530a-a52a-3acf1b5c6d15","slug":"imp-study-p38gamma-assay","display_name":"p38-gamma assay protein in the 2018 ImP study; 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study also contains mouse intervention and human observations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The abstract does not resolve species and construct for each biochemical step; assay proteins are not silently assigned human identity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Histidine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A kinase relays the microbial-metabolite signal to an adaptor protein.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30401435/ · DOI 10.1016/j.cell.2018.09.055","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"dc2974cc-e42d-5942-86f2-cb6736621aeb","evidence_kind":"source_excerpt","locator":"Lines 306-312","start_line":306,"end_line":312,"excerpt":"## histidine-imp-p38-p62\nA kinase relays the microbial-metabolite signal to an adaptor protein.\nThe 2018 study linked imidazole-propionate-activated p38-gamma to p62 phosphorylation.\nModel: Biochemical/cellular experiments summarized in the primary abstract; study also contains mouse intervention and human observations.\nLimitations: The abstract does not resolve species and construct for each biochemical step; assay proteins are not silently assigned human identity.\nEvidence access: Primary abstract\nMicrobially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30401435/ · DOI 10.1016/j.cell.2018.09.055","model_system":"Biochemical/cellular experiments summarized in the primary abstract; study also contains mouse intervention and human observations.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"ce59e6c9-1213-523b-9d0b-400b7a81cd1c","stable_key":"import-911fb3c7-8cc3-5667-b677-5682fab67648","title":"L-Histidine: supply, catabolism, histamine, receptors and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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