{"id":"36fac26e-ce80-5177-a7e2-80efcd430c77","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-6-plcb-null","predicate":"does_not_inhibit","statement":"6-Gingerol did not share the PLC beta inhibition reported for 8-gingerol and 6-shogaol in this comparison.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"ce4b0c11-7248-5e0c-ad30-1765b418f94f","mechanism_event_label":"6-Gingerol did not share the PLC beta inhibition reported for 8-gingerol and 6-shogaol in this comparison.","subject":{"id":"837fdd65-c1eb-52e0-a724-42a1e9065c82","slug":"6-gingerol","display_name":"6-Gingerol","entity_type_key":"small_molecule"},"object":{"id":"2063e4c8-abd3-5766-9b00-f3bcd53dfb09","slug":"townsend-purified-plcb-preparation","display_name":"Purified phospholipase C beta preparation in the Townsend study","entity_type_key":"protein_family"},"evidence_count":1,"mechanism_event":{"id":"ce4b0c11-7248-5e0c-ad30-1765b418f94f","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-6-plcb-null-event","event_type":"observed_relationship","label":"6-Gingerol did not share the PLC beta inhibition reported for 8-gingerol and 6-shogaol in this comparison.","description":"6-Gingerol did not share the PLC beta inhibition reported for 8-gingerol and 6-shogaol in this comparison.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"837fdd65-c1eb-52e0-a724-42a1e9065c82","slug":"6-gingerol","display_name":"6-Gingerol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2063e4c8-abd3-5766-9b00-f3bcd53dfb09","slug":"townsend-purified-plcb-preparation","display_name":"Purified phospholipase C beta preparation in the Townsend study","entity_type_key":"protein_family"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Ginger constituent enzyme assay; study used 100 micromolar in tissue experiments, enzyme-assay exposure details not resolved here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Not specified in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Purified PDE4D and PLC beta enzyme preparations","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Preparation species and PLC beta isoform are unresolved; do not label these as a proven specific human tissue target. Comparative enzyme response; not a universal absence of PLC-related cellular effects.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gingerols collection; each molecular form and experimental preparation remains explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gingerols","display_name":"Gingerols","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Purified PDE4D and PLC beta enzyme preparations","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"6-Gingerol did not share the PLC beta inhibition reported for 8-gingerol and 6-shogaol in this comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins. (2014). https://pubmed.ncbi.nlm.nih.gov/23962082/ DOI: 10.1165/rcmb.2013-0133OC","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro addition","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Cell-free enzyme assays","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"48127629-4924-5845-a3d2-02b2795eedf1","evidence_kind":"source_excerpt","locator":"Lines 239-248","start_line":239,"end_line":248,"excerpt":"## gingerols-6-plcb-null\n6-Gingerol did not share the PLC beta inhibition reported for 8-gingerol and 6-shogaol in this comparison.\nModel/species: Purified PDE4D and PLC beta enzyme preparations\nTissue: Cell-free enzyme assays\nExposure: Ginger constituent enzyme assay; study used 100 micromolar in tissue experiments, enzyme-assay exposure details not resolved here\nRoute: In vitro addition\nDuration: Not specified in accessed abstract\nLimits: Preparation species and PLC beta isoform are unresolved; do not label these as a proven specific human tissue target. Comparative enzyme response; not a universal absence of PLC-related cellular effects.\nPrimary reference: Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins. 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