{"id":"36eacfd6-6bc2-546d-951f-c73d8dff65a3","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:renal-cellular-k-depletion-lowers-mg-influx","predicate":"depletion-decreases","statement":"Potassium-depleted MDCT cells showed reduced Mg2+ uptake in a magnesium-recovery assay.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"7b59d2f3-d570-538a-ad0d-7ef4dcd7ca68","mechanism_event_label":"Depleting cellular potassium made it harder for these kidney cells to take up magnesium.","subject":{"id":"bdbdaac4-5d0b-5a31-a738-b4a4ed734bcc","slug":"intracellular-potassium-content","display_name":"Intracellular potassium content","entity_type_key":"cellular_process"},"object":{"id":"2c31af15-4eba-5fdc-9a37-11104bd19c82","slug":"cellular-magnesium-influx","display_name":"Cellular magnesium influx","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7b59d2f3-d570-538a-ad0d-7ef4dcd7ca68","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:renal-cellular-k-depletion-lowers-mg-influx-event","event_type":"biochemical_relationship","label":"Depleting cellular potassium made it harder for these kidney cells to take up magnesium.","description":"Potassium-depleted MDCT cells showed reduced Mg2+ uptake in a magnesium-recovery assay.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bdbdaac4-5d0b-5a31-a738-b4a4ed734bcc","slug":"intracellular-potassium-content","display_name":"Intracellular potassium content","entity_type_key":"cellular_process"},"role":"causal-subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2c31af15-4eba-5fdc-9a37-11104bd19c82","slug":"cellular-magnesium-influx","display_name":"Cellular magnesium influx","entity_type_key":"cellular_process"},"role":"measured-target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"depleted-ion","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"transported-ion","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"fba9caf6-526d-55ba-895e-0c9878c864ea","slug":"dct-membrane-potential","display_name":"DCT membrane potential","entity_type_key":"cellular_process"},"role":"proposed-intermediate","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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fluorescence Mg-recovery assay","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [dai-1997-k-mg] Cellular mechanisms of chlorothiazide and cellular potassium depletion on Mg2+ uptake in mouse distal convoluted tubule cells (1997). https://pubmed.ncbi.nlm.nih.gov/9083264/ DOI: 10.1038/ki.1997.141","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}