{"id":"36e3dcc7-e917-58d2-9bc7-47e3feed9a83","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:cal-bedtime-activity-product","predicate":"has_reported_effect_on","statement":"Urinary calcium-oxalate activity product increased after bedtime calcium carbonate but not after meal dosing.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"990f238d-ddec-5b86-b234-b6944c381462","mechanism_event_label":"The urinary crystallization proxy depended on timing.","subject":{"id":"4ee1cbd0-1cec-58e1-9fee-bdb2c13db94d","slug":"calcium-carbonate","display_name":"Calcium carbonate","entity_type_key":"chemical_species"},"object":{"id":"6100d1be-7179-5faa-8809-0dec8ad816b4","slug":"calcium-oxalate-activity-product","display_name":"Urinary calcium oxalate activity product","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"990f238d-ddec-5b86-b234-b6944c381462","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:cal-bedtime-activity-product-event","event_type":"observed_intervention","label":"The urinary crystallization proxy depended on timing.","description":"Urinary calcium-oxalate activity product increased after bedtime calcium carbonate but not after meal dosing.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4ee1cbd0-1cec-58e1-9fee-bdb2c13db94d","slug":"calcium-carbonate","display_name":"Calcium carbonate","entity_type_key":"chemical_species"},"role":"tested_input","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6100d1be-7179-5faa-8809-0dec8ad816b4","slug":"calcium-oxalate-activity-product","display_name":"Urinary calcium oxalate activity product","entity_type_key":"cellular_process"},"role":"measured_outcome","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"urinary_ion","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9c8d2b72-517d-5bb6-8589-cabd98267f65","slug":"oxalate","display_name":"Oxalate","entity_type_key":"ion"},"role":"urinary_ion","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Same short crossover experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A saturation-related proxy is not an observed kidney-stone event or a universal prediction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The urinary crystallization proxy depended on timing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cal-clin-domrong2004] Schedule of taking calcium supplement and the risk of nephrolithiasis (2004). https://pubmed.ncbi.nlm.nih.gov/15086924/ DOI: 10.1111/j.1523-1755.2004.00587.x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human clinical or absorption endpoint","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9a67e02d-bef6-50ec-b86d-3cc762d644a2","evidence_kind":"source_excerpt","locator":"Lines 1270-1279","start_line":1270,"end_line":1279,"excerpt":"### cal-bedtime-activity-product\nUrinary calcium-oxalate activity product increased after bedtime calcium carbonate but not after meal dosing.\nCondition category: normal\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The urinary crystallization proxy depended on timing.\norganism: Homo sapiens\ntissue_or_cell_type: Human clinical or absorption endpoint\nexperimental_model: Same short crossover experiment.\nlimitations: A saturation-related proxy is not an observed kidney-stone event or a universal prediction.\n[cal-clin-domrong2004] Schedule of taking calcium supplement and the risk of nephrolithiasis (2004). https://pubmed.ncbi.nlm.nih.gov/15086924/ DOI: 10.1111/j.1523-1755.2004.00587.x","model_system":"Same short crossover experiment.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [cal-clin-domrong2004] Schedule of taking calcium supplement and the risk of nephrolithiasis (2004). https://pubmed.ncbi.nlm.nih.gov/15086924/ DOI: 10.1111/j.1523-1755.2004.00587.x","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3c083fa0-59c6-50e9-af42-678d0e3c1006","stable_key":"import-434e1e27-eb90-583a-956b-62472726ffba","title":"Calcium: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"965c934d6b147f2b62f8d45ce6d7a87681a600bfe5c46a585b4704889afd3fc1","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}