{"id":"369cd39b-bc9e-5048-ae2b-6214b2aa8b6d","stable_key":"7484635e-cc8f-5cd6-a978-6dc5775a7db5:berberine-adenoma-recurrence","predicate":"reduces","statement":"Adenomas recurred in 36% of analyzed berberine participants versus 47% with placebo; relative risk 0.77, 95% CI 0.66-0.91.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"55bac331-4d7e-5841-aed0-1acf72666e69","mechanism_event_label":"A randomized study measured fewer recurrent polyps after their removal.","subject":{"id":"7bbe0633-b2f1-510f-adc0-3c4d0ddad05d","slug":"berberine","display_name":"Berberine","entity_type_key":"small_molecule"},"object":{"id":"4c47991c-d43e-542e-b061-839709a6c320","slug":"colorectal-adenoma-recurrence","display_name":"Colorectal adenoma recurrence","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"55bac331-4d7e-5841-aed0-1acf72666e69","stable_key":"7484635e-cc8f-5cd6-a978-6dc5775a7db5:berberine-adenoma-recurrence-event","event_type":"observed_intervention","label":"A randomized study measured fewer recurrent polyps after their removal.","description":"Adenomas recurred in 36% of analyzed berberine participants versus 47% with placebo; relative risk 0.77, 95% CI 0.66-0.91.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7bbe0633-b2f1-510f-adc0-3c4d0ddad05d","slug":"berberine","display_name":"Berberine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4c47991c-d43e-542e-b061-839709a6c320","slug":"colorectal-adenoma-recurrence","display_name":"Colorectal adenoma recurrence","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/berberine-research/31926918.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0045a39cfd796c9db7aa81e0a9c4bea8004396e137d842519e03664560c4878c\", \"start_char\": 0, \"end_char\": 2466, \"text_sha256\": \"0045a39cfd796c9db7aa81e0a9c4bea8004396e137d842519e03664560c4878c\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Multicenter double-blind randomized placebo-controlled trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Berberine 0.3 g twice daily; colonoscopy follow-up up to two years","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Modified intention-to-treat analysis excluded participants without efficacy data. Adenoma recurrence is not colorectal-cancer mortality or proof of cancer treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Berberine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"berberine","display_name":"Berberine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Adults after colorectal polypectomy; 1108 randomized, 891 in full analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A randomized study measured fewer recurrent polyps after their removal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[berberine-p31926918] Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study. (2020). https://pubmed.ncbi.nlm.nih.gov/31926918/ DOI: 10.1016/s2468-1253(19)30409-1","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Adenoma recurrence","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6c7fbc2e-3166-53ba-a153-1313d8b665ff","evidence_kind":"source_excerpt","locator":"Lines 1299-1310","start_line":1299,"end_line":1310,"excerpt":"### berberine-adenoma-recurrence\nAdenomas recurred in 36% of analyzed berberine participants versus 47% with placebo; relative risk 0.77, 95% CI 0.66-0.91.\nCondition category: normal\nnutrient_topic: Berberine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A randomized study measured fewer recurrent polyps after their removal.\norganism: Adults after colorectal polypectomy; 1108 randomized, 891 in full analysis\ntissue_or_cell_type: Adenoma recurrence\nexperimental_model: Multicenter double-blind randomized placebo-controlled trial\nlimitations: Modified intention-to-treat analysis excluded participants without efficacy data. Adenoma recurrence is not colorectal-cancer mortality or proof of cancer treatment.\nexposure: Berberine 0.3 g twice daily; colonoscopy follow-up up to two years\nevidence_span: {\"source_cache\": \"artifacts/berberine-research/31926918.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0045a39cfd796c9db7aa81e0a9c4bea8004396e137d842519e03664560c4878c\", \"start_char\": 0, \"end_char\": 2466, \"text_sha256\": \"0045a39cfd796c9db7aa81e0a9c4bea8004396e137d842519e03664560c4878c\"}\n[berberine-p31926918] Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study. (2020). https://pubmed.ncbi.nlm.nih.gov/31926918/ DOI: 10.1016/s2468-1253(19)30409-1","model_system":"Multicenter double-blind randomized placebo-controlled trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [berberine-p31926918] Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study. (2020). https://pubmed.ncbi.nlm.nih.gov/31926918/ DOI: 10.1016/s2468-1253(19)30409-1","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"9bb61e1d-e5cf-5b05-a9ca-409291f7a313","stable_key":"import-7484635e-cc8f-5cd6-a978-6dc5775a7db5","title":"Berberine: metabolism, nutrient connections and drug interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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