{"id":"3678fc34-61f8-56d1-86dc-5e570e73a00c","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-healthy-null","predicate":"does_not_improve","statement":"Seven healthy active adults showed no improvement in fasting glucose, fasting insulin or OGTT-derived insulin-sensitivity index after one or seven days of vanadyl sulfate.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"90d669f1-5e89-561e-bcb4-71486397f5d0","mechanism_event_label":"The small healthy-volunteer study did not show the hoped-for insulin benefit.","subject":{"id":"68c1e8ab-2afe-5c6e-bae1-45b9bb505795","slug":"vanadyl-sulfate","display_name":"Vanadyl sulfate","entity_type_key":"chemical_species"},"object":{"id":"4a3d758d-3ad9-5155-8d88-33b412c41aad","slug":"human-healthy-vanadyl-insulin-sensitivity","display_name":"Insulin sensitivity in healthy active adults after vanadyl","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"90d669f1-5e89-561e-bcb4-71486397f5d0","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-healthy-null-event","event_type":"observed_relationship","label":"The small healthy-volunteer study did not show the hoped-for insulin benefit.","description":"Seven healthy active adults showed no improvement in fasting glucose, fasting insulin or OGTT-derived insulin-sensitivity index after one or seven days of vanadyl sulfate.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"68c1e8ab-2afe-5c6e-bae1-45b9bb505795","slug":"vanadyl-sulfate","display_name":"Vanadyl sulfate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4a3d758d-3ad9-5155-8d88-33b412c41aad","slug":"human-healthy-vanadyl-insulin-sensitivity","display_name":"Insulin sensitivity in healthy active adults after vanadyl","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c5cbad45-22c6-594b-ab6b-71880dab1b24","slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"One hundred mg before acute testing, then 50 mg twice daily for six days; within-person design.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small short study without a randomized placebo comparator; not proof of no effect at every exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vanadium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"The small healthy-volunteer study did not show the hoped-for insulin benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effect of acute and short-term administration of vanadyl sulphate on insulin sensitivity in healthy active humans. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12500990/ · DOI 10.1123/ijsnem.12.4.470","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fb1f24d7-b6fb-55ff-8d74-c1844832d32e","evidence_kind":"source_excerpt","locator":"Lines 446-452","start_line":446,"end_line":452,"excerpt":"## vanadium-healthy-null\nThe small healthy-volunteer study did not show the hoped-for insulin benefit.\nSeven healthy active adults showed no improvement in fasting glucose, fasting insulin or OGTT-derived insulin-sensitivity index after one or seven days of vanadyl sulfate.\nModel: One hundred mg before acute testing, then 50 mg twice daily for six days; within-person design.\nLimitations: Small short study without a randomized placebo comparator; not proof of no effect at every exposure.\nEvidence access: Primary abstract\nEffect of acute and short-term administration of vanadyl sulphate on insulin sensitivity in healthy active humans. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12500990/ · DOI 10.1123/ijsnem.12.4.470","model_system":"One hundred mg before acute testing, then 50 mg twice daily for six days; within-person design.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e4d5d0ba-529b-540f-96ed-e719d116ccfd","stable_key":"import-335be270-ea4a-5c8e-ad04-964fd22a439e","title":"Vanadium: speciation, phosphate-sensitive enzymes and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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