{"id":"36394734-04f8-5386-94e4-4483817971cf","stable_key":"c94a9824-35fb-523c-b421-dc7341218dcb:indicaxanthin-human-fruit-fmri-null","predicate":"no_detected_change","statement":"The six-person imaging subgroup showed no significant resting-state connectivity change after the fruit meal.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"aac742ab-7fbc-5090-95ad-f3fb88bf2049","mechanism_event_label":"The six-person imaging subgroup showed no significant resting-state connectivity change after the fruit meal.","subject":{"id":"c8b229b8-496f-55a0-8b58-f1f950d42e68","slug":"cactus-pear-2022-neurostimulation-meal","display_name":"Cactus pear fruit meal in the 2022 neurostimulation study","entity_type_key":"small_molecule"},"object":{"id":"27c5912f-3bb9-52c9-a574-2b422d4b4aea","slug":"human-resting-state-fmri-connectivity","display_name":"Human resting-state fMRI connectivity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"aac742ab-7fbc-5090-95ad-f3fb88bf2049","stable_key":"c94a9824-35fb-523c-b421-dc7341218dcb:indicaxanthin-human-fruit-fmri-null-event","event_type":"observed_relationship","label":"The six-person imaging subgroup showed no significant resting-state connectivity change after the fruit meal.","description":"The six-person imaging subgroup showed no significant resting-state connectivity change after the fruit meal.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c8b229b8-496f-55a0-8b58-f1f950d42e68","slug":"cactus-pear-2022-neurostimulation-meal","display_name":"Cactus pear fruit meal in the 2022 neurostimulation study","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"27c5912f-3bb9-52c9-a574-2b422d4b4aea","slug":"human-resting-state-fmri-connectivity","display_name":"Human resting-state fMRI connectivity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f2a6e469-05f0-5596-9054-da926389f584","slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"400 g yellow cactus pear","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Baseline and 90 min after consumption","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary open full text, relevant results/methods and PubMed metadata.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Six healthy participants in exploratory imaging subgroup","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small imaging subgroup; a null imaging comparison does not exclude every neural effect. Whole-fruit exposure does not isolate indicaxanthin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Dedicated indicaxanthin chapter; original betalain family identity and shared claims preserved.","comparator":null,"unit":null,"notes":"","entity":{"slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Six healthy participants in exploratory imaging subgroup","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The six-person imaging subgroup showed no significant resting-state connectivity change after the fruit meal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Modulation of Human Motor Cortical Excitability and Plasticity by Opuntia Ficus Indica Fruit Consumption: Evidence from a Preliminary Study through Non-Invasive Brain Stimulation. (2022). https://pubmed.ncbi.nlm.nih.gov/36432601/ DOI: 10.3390/nu14224915","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral whole fruit","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Resting-state brain networks","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"db18673e-e02f-5b71-87c0-3407760f0cd9","evidence_kind":"source_excerpt","locator":"Lines 272-281","start_line":272,"end_line":281,"excerpt":"## indicaxanthin-human-fruit-fmri-null\nThe six-person imaging subgroup showed no significant resting-state connectivity change after the fruit meal.\nModel/species: Six healthy participants in exploratory imaging subgroup\nTissue: Resting-state brain networks\nExposure: 400 g yellow cactus pear\nRoute: Oral whole fruit\nDuration: Baseline and 90 min after consumption\nLimits: Small imaging subgroup; a null imaging comparison does not exclude every neural effect. Whole-fruit exposure does not isolate indicaxanthin.\nPrimary reference: Modulation of Human Motor Cortical Excitability and Plasticity by Opuntia Ficus Indica Fruit Consumption: Evidence from a Preliminary Study through Non-Invasive Brain Stimulation. (2022). https://pubmed.ncbi.nlm.nih.gov/36432601/ DOI: 10.3390/nu14224915\nAccess: Primary open full text, relevant results/methods and PubMed metadata.","model_system":"Six healthy participants in exploratory imaging subgroup","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived curation span; original paraphrase with primary citation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"18b7303c-98b7-54cb-ae8e-a8c6257657b1","stable_key":"import-c94a9824-35fb-523c-b421-dc7341218dcb","title":"Indicaxanthin: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen additional primary studies, with twenty-six existing claims from eight studies linked unchanged. Study-specific citations and limitations retained. Not publisher full text.","file_path":"","sha256":"fd5e7b3a108073af5a8cad0e226a483ae2cda3b0e1daed387553ee441acecd5f","revision_id":"f3357c22-1be7-5502-b4f5-415d19c3cf5a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}