{"id":"36305ded-a1dc-5a64-9f1b-43170c48d64c","stable_key":"4df6a932-097e-563a-91fe-5dceec471ffd:chloride-repletion-control","predicate":"no_detected_effect_on","statement":"The same KCl load did not change acid–base status in sodium-depleted subjects who were not chloride-depleted.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"7fc8055c-96aa-510d-bd42-217b6eb57583","mechanism_event_label":"The response depended on chloride depletion, not merely on receiving KCl.","subject":{"id":"9a56258e-7dda-5b6a-9a14-58c9fe1856c3","slug":"potassium-chloride","display_name":"Potassium chloride","entity_type_key":"chemical_species"},"object":{"id":"d838c3fe-9d18-5c31-a014-ffc943cb0f58","slug":"plasma-bicarbonate-concentration","display_name":"Plasma bicarbonate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7fc8055c-96aa-510d-bd42-217b6eb57583","stable_key":"4df6a932-097e-563a-91fe-5dceec471ffd:chloride-repletion-control-event","event_type":"observed_intervention","label":"The response depended on chloride depletion, not merely on receiving KCl.","description":"The same KCl load did not change acid–base status in sodium-depleted subjects who were not chloride-depleted.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9a56258e-7dda-5b6a-9a14-58c9fe1856c3","slug":"potassium-chloride","display_name":"Potassium chloride","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d838c3fe-9d18-5c31-a014-ffc943cb0f58","slug":"plasma-bicarbonate-concentration","display_name":"Plasma bicarbonate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chloride-research/2450456.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3df006f26c20c11aeb8fd26884ccbd5d1389921d34a40adad6f72edc184360d7\", \"start_char\": 0, \"end_char\": 1348, \"text_sha256\": \"3df006f26c20c11aeb8fd26884ccbd5d1389921d34a40adad6f72edc184360d7\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human depletion–repletion balance experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Furosemide plus restricted NaCl; oral KCl repletion over 36 hours","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Loss-associated depletion; KCl supplies potassium too. Mechanism does not imply self-treatment or apply to every alkalosis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chloride research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chloride","display_name":"Chloride","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The response depended on chloride depletion, not merely on receiving KCl.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chloride-p2450456] On the mechanism by which chloride corrects metabolic alkalosis in man. (1988). https://pubmed.ncbi.nlm.nih.gov/2450456/ DOI: 10.1016/0002-9343(88)90265-3","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Kidney and systemic acid–base balance","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c4ff68a1-947c-5f0a-bb94-e1b1dafd5a36","evidence_kind":"source_excerpt","locator":"Lines 861-872","start_line":861,"end_line":872,"excerpt":"### chloride-repletion-control\nThe same KCl load did not change acid–base status in sodium-depleted subjects who were not chloride-depleted.\nCondition category: normal\nnutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The response depended on chloride depletion, not merely on receiving KCl.\norganism: Human men\ntissue_or_cell_type: Kidney and systemic acid–base balance\nexperimental_model: Human depletion–repletion balance experiment\nlimitations: Loss-associated depletion; KCl supplies potassium too. Mechanism does not imply self-treatment or apply to every alkalosis.\nexposure: Furosemide plus restricted NaCl; oral KCl repletion over 36 hours\nevidence_span: {\"source_cache\": \"artifacts/chloride-research/2450456.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3df006f26c20c11aeb8fd26884ccbd5d1389921d34a40adad6f72edc184360d7\", \"start_char\": 0, \"end_char\": 1348, \"text_sha256\": \"3df006f26c20c11aeb8fd26884ccbd5d1389921d34a40adad6f72edc184360d7\"}\n[chloride-p2450456] On the mechanism by which chloride corrects metabolic alkalosis in man. (1988). https://pubmed.ncbi.nlm.nih.gov/2450456/ DOI: 10.1016/0002-9343(88)90265-3","model_system":"Human depletion–repletion balance experiment","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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