{"id":"35ed2c7d-30ee-54b8-86f7-0c602434bf61","stable_key":"c156003d-8cdf-5259-8561-9803795ecc82:crc-glv9-growth","predicate":"reduces","statement":"GL-V9 reportedly suppressed colorectal-cancer growth in the study models.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"34196d99-b114-5354-b1c4-9508e8e32eae","mechanism_event_label":"crc glv9 growth","subject":{"id":"a33befce-aea9-5427-b66b-199357e3da6c","slug":"gl-v9","display_name":"GL-V9","entity_type_key":"drug"},"object":{"id":"e7dab92c-7405-5e69-9024-1a59b55caf68","slug":"crc-growth-model-endpoint","display_name":"Colorectal cancer growth in study models","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"34196d99-b114-5354-b1c4-9508e8e32eae","stable_key":"c156003d-8cdf-5259-8561-9803795ecc82:crc-glv9-growth","event_type":"reduces","label":"crc glv9 growth","description":"Model-specific finding; read linked claim context and source-access tier.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a33befce-aea9-5427-b66b-199357e3da6c","slug":"gl-v9","display_name":"GL-V9","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e7dab92c-7405-5e69-9024-1a59b55caf68","slug":"crc-growth-model-endpoint","display_name":"Colorectal cancer growth in study models","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"access_level","value_text":"abstract_only","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"compartment","value_text":"Mitochondrial GSH versus intracellular GSH distinguished by authors","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"dose","value_text":"Unknown: full methods unavailable","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Unknown: full methods unavailable","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"endpoint","value_text":"crc-growth-model-endpoint","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract; experiment-specific methods unavailable","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Protein interaction/stability, knockdown and compound experiments reported in abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"gl-v9","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"ABSTRACT-ONLY CURATION. 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Full article and supplements were not accessible; assay-specific cell line, dose, timing, controls and sample size remain unverified. No pulmonary-endothelial or clinical-treatment inference. The abstract does not establish model-specific dosing, safety or clinical efficacy.\nprimary_locator: [{\"cache\": \"artifacts/dlat-curation/crc-metadata.json\", \"json_path\": \"resultList.result[0].abstractText\", \"access\": \"abstract_only\"}]\nplain_language: GL-V9 reportedly suppressed colorectal-cancer growth in the study models.","model_system":"Protein interaction/stability, knockdown and compound experiments reported in abstract","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Quotation is the authored curation, not original publisher wording. Exact primary locators and access limits retained in contexts.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"ee72956d-4fd4-58d3-9a94-e173bb1e3282","stable_key":"import-c156003d-8cdf-5259-8561-9803795ecc82","title":"DLAT: cardiac fatty-acid oxidation and mitochondrial glutathione evidence","document_type":"imported_text","citation_label":"AI-assisted two-paper curation, 2026-09-20. Cardiac full-text/supplement review; CRC abstract only. No pulmonary endothelial validation.","file_path":"","sha256":"159e5472c8b1d104625f9c648dc9ee24dcd5fe102109fd960bba50e9ba9de954","revision_id":"5ca6b1f1-fd75-5f8d-ba2b-0215fbf387c7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}