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species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"agmatine-sulfate","display_name":"Agmatine Sulfate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Competition depends on which cell and transport route is being studied.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Transport and metabolism of agmatine in rat hepatocyte cultures. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11179960/ · DOI 10.1046/j.1432-1327.2001.01955.x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_effect","value_text":"raises","comparator":null,"unit":null,"notes":"Hepatocytes showed high-affinity agmatine uptake with a Km of 0.03 mM.","entity":null},{"dimension":"transport_pool","value_text":"the hepatocyte interior","comparator":null,"unit":null,"notes":"Hepatocytes showed high-affinity agmatine uptake with a Km of 0.03 mM.","entity":null}],"evidence":[{"id":"2b070d32-dcbb-5519-8f8f-0a23a7173036","evidence_kind":"source_excerpt","locator":"Lines 76-82","start_line":76,"end_line":82,"excerpt":"## agmatine-sulfate-rat-liver-uptake\nCompetition depends on which cell and transport route is being studied.\nRat hepatocytes exhibited high-affinity agmatine uptake with Km 0.03 mM; the system also transported putrescine but not arginine, spermidine or spermine.\nModel: Primary rat hepatocyte cultures and radiolabeled substrate.\nLimitations: Different selectivity from other polyamine uptake systems is a context difference, not a universal contradiction.\nEvidence access: Primary abstract\nTransport and metabolism of agmatine in rat hepatocyte cultures. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11179960/ · DOI 10.1046/j.1432-1327.2001.01955.x","model_system":"Primary rat hepatocyte cultures and radiolabeled substrate.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e0426971-7d13-51c9-8354-6547b664f1cf","stable_key":"import-220adaab-10d8-5c4e-a3f5-a48700ea794d","title":"Agmatine Sulfate: transport, guanidino metabolism, ion channels and cross-nutrient mechanisms (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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