{"id":"354beb70-031d-527a-988a-c3352e77bc2e","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-air-serum","predicate":"increases","statement":"A single 130 mg oral KI exposure increased serum iodide in human volunteers.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"bdc82f3f-8eba-55dc-8d0c-edae77315850","mechanism_event_label":"Oral KI raised circulating iodide.","subject":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"object":{"id":"9d450957-d2a0-547f-9145-cf9ff6b3e0c9","slug":"serum-iodide-concentration","display_name":"Serum iodide concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"bdc82f3f-8eba-55dc-8d0c-edae77315850","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-air-serum-event","event_type":"observed_relationship","label":"Oral KI raised circulating iodide.","description":"A single 130 mg oral KI exposure increased serum iodide in human volunteers.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9d450957-d2a0-547f-9145-cf9ff6b3e0c9","slug":"serum-iodide-concentration","display_name":"Serum iodide concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Primary airway epithelial cultures and human oral-KI exposure; separate experimental arms.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Culture antiviral activity and human secretion measurements do not establish prevention or treatment of human infection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Oral KI raised circulating iodide.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Enhancement of respiratory mucosal antiviral defenses by the oxidation of iodide. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21441383/ · DOI 10.1165/rcmb.2010-0329oc","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"69265b69-d8dc-5403-b822-c0da3fa6e4e3","evidence_kind":"source_excerpt","locator":"Lines 56-62","start_line":56,"end_line":62,"excerpt":"## ki-air-serum\nOral KI raised circulating iodide.\nA single 130 mg oral KI exposure increased serum iodide in human volunteers.\nModel: Primary airway epithelial cultures and human oral-KI exposure; separate experimental arms.\nLimitations: Culture antiviral activity and human secretion measurements do not establish prevention or treatment of human infection.\nEvidence location: Primary abstract\nEnhancement of respiratory mucosal antiviral defenses by the oxidation of iodide. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21441383/ · DOI 10.1165/rcmb.2010-0329oc","model_system":"Primary airway epithelial cultures and human oral-KI exposure; separate experimental arms.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-study references, chemical references and label statements individually identified. Not publisher full text.","file_path":"","sha256":"3ff9da818dd7a763a59c6abcff2eaee136d7f887a777034feaa5ba304a8fa6ce","revision_id":"53f2ae88-8a91-5326-ac49-3bb510ca78c3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}