{"id":"35467457-41eb-598e-b6e3-c6dc5ca61e8f","stable_key":"e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff:nasunin-paraquat-weight","predicate":"attenuated_challenge_induced_decrease_in","statement":"Nasunin attenuated the paraquat-associated reduction in body weight gain.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"21d25d0a-cd23-55a0-a71f-abe6328d8f9b","mechanism_event_label":"Weight gain was better preserved during cofeeding.","subject":{"id":"6553997f-f098-5507-95b4-0fdb8aac491d","slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"},"object":{"id":"3e8f1931-209a-53f2-9a7b-6a666c8603e9","slug":"rat-body-weight-gain","display_name":"Rat body weight gain","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"21d25d0a-cd23-55a0-a71f-abe6328d8f9b","stable_key":"e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff:nasunin-paraquat-weight-event","event_type":"biochemical_relationship","label":"Weight gain was better preserved during cofeeding.","description":"Nasunin attenuated the paraquat-associated reduction in body weight gain.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6db3a6ae-843d-58e3-a5ab-9394fbba6eff","slug":"paraquat","display_name":"Paraquat","entity_type_key":"small_molecule"},"role":"challenge","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6553997f-f098-5507-95b4-0fdb8aac491d","slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"3e8f1931-209a-53f2-9a7b-6a666c8603e9","slug":"rat-body-weight-gain","display_name":"Rat body weight gain","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/nasunin-research/10380622.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8100a5a5537ebfde9e6d82e3c71aeb3aed980c58b2f3ae9b27400258324d1a69\", \"start_char\": 0, \"end_char\": 1009, \"text_sha256\": \"8100a5a5537ebfde9e6d82e3c71aeb3aed980c58b2f3ae9b27400258324d1a69\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Dietary paraquat challenge with nasunin cofeeding","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Paraquat-containing diet with or without nasunin; dose not specified in indexed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Preventive cofeeding is not a human poisoning treatment. A mitochondrial-fraction catalase assay does not establish mitochondrial localization of catalase.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Nasunin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rats","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Weight gain was better preserved during cofeeding.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[nasunin-p10380622] Protective effects of dietary nasunin on paraquat-induced oxidative stress in rats. (1999). https://pubmed.ncbi.nlm.nih.gov/10380622/ DOI: 10.1271/bbb.63.799","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver redox markers and whole-animal responses","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"bda23973-2780-555d-92cf-444e410fee6e","evidence_kind":"source_excerpt","locator":"Lines 861-872","start_line":861,"end_line":872,"excerpt":"### nasunin-paraquat-weight\nNasunin attenuated the paraquat-associated reduction in body weight gain.\nCondition category: normal\nnutrient_topic: Nasunin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Weight gain was better preserved during cofeeding.\norganism: Rats\ntissue_or_cell_type: Liver redox markers and whole-animal responses\nexperimental_model: Dietary paraquat challenge with nasunin cofeeding\nlimitations: Preventive cofeeding is not a human poisoning treatment. A mitochondrial-fraction catalase assay does not establish mitochondrial localization of catalase.\nexposure: Paraquat-containing diet with or without nasunin; dose not specified in indexed abstract\nevidence_span: {\"source_cache\": \"artifacts/nasunin-research/10380622.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8100a5a5537ebfde9e6d82e3c71aeb3aed980c58b2f3ae9b27400258324d1a69\", \"start_char\": 0, \"end_char\": 1009, \"text_sha256\": \"8100a5a5537ebfde9e6d82e3c71aeb3aed980c58b2f3ae9b27400258324d1a69\"}\n[nasunin-p10380622] Protective effects of dietary nasunin on paraquat-induced oxidative stress in rats. (1999). https://pubmed.ncbi.nlm.nih.gov/10380622/ DOI: 10.1271/bbb.63.799","model_system":"Dietary paraquat challenge with nasunin cofeeding","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [nasunin-p10380622] Protective effects of dietary nasunin on paraquat-induced oxidative stress in rats. (1999). https://pubmed.ncbi.nlm.nih.gov/10380622/ DOI: 10.1271/bbb.63.799","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2c43df19-ccb0-58f1-b9a4-bc92cda6de5a","stable_key":"import-e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff","title":"Nasunin: identity, redox chemistry and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"56552c208433294bf9a6c95513d981dbe4d00fd8336c121816d7b8bd6604d50e","revision_id":"b0296d49-32d7-52dc-a23c-5e862da0fba3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}