{"id":"350fb2df-08ad-58e5-8cd2-9cf1c6be650d","stable_key":"availability:limited-selenium-sec-trna:1","predicate":"can_limit_availability_of","statement":"When selenium availability falls, the Sec-tRNA supply can become constrained.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"source_reported: Cell/biochemical mechanism; source-derived unverified synthesis.","direction":"negative","is_public":true,"mechanism_event_id":"be197810-8c7a-5b37-9b87-0414a4f2c9fc","mechanism_event_label":"When selenium availability falls, the Sec-tRNA supply can become constrained.","subject":{"id":"dc89d7e2-8f89-577b-838f-42bf5d8ec7c8","slug":"selenium","display_name":"Selenium","entity_type_key":"nutrient_element"},"object":{"id":"15ce9978-f9e2-528c-8a2f-1079154b5383","slug":"sec-trna","display_name":"Sec-tRNA[Ser]Sec","entity_type_key":"rna"},"evidence_count":1,"mechanism_event":{"id":"be197810-8c7a-5b37-9b87-0414a4f2c9fc","stable_key":"availability:limited-selenium-sec-trna:1","event_type":"availability_dependent_change","label":"When selenium availability falls, the Sec-tRNA supply can become constrained.","description":"Selenium intake or availability becomes inadequate for the cellular context. Biochemical pathway and experimental shortage model; effects depend on transcript and tissue.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dc89d7e2-8f89-577b-838f-42bf5d8ec7c8","slug":"selenium","display_name":"Selenium","entity_type_key":"nutrient_element"},"role":"condition_input","stoichiometry":null,"state_label":"Selenium intake or availability becomes inadequate for the cellular context.","sequence_order":0,"notes":""},{"entity":{"id":"15ce9978-f9e2-528c-8a2f-1079154b5383","slug":"sec-trna","display_name":"Sec-tRNA[Ser]Sec","entity_type_key":"rna"},"role":"affected_component","stoichiometry":null,"state_label":"Selenium intake or availability becomes inadequate for the cellular context.","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"Selenium intake or availability becomes inadequate for the cellular context.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_scope","value_text":"Biochemical pathway and experimental shortage model; effects depend on transcript and tissue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This is a conditional supply constraint, not a prediction that all selenoproteins fall equally. No validated plasma cutoff is assigned.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a7cc611c-beeb-5045-a6b7-c1f1f71df197","evidence_kind":"source_passage","locator":"lines 783-790","start_line":783,"end_line":790,"excerpt":"selenium intake / availability ↓\n        │\n        ▼\ncentral selenium metabolism and Sec-tRNA supply become constrained\n        │\n        ├─ tRNA^[Ser]Sec modification can shift (including Um34 / FTSJ1 biology)\n        ├─ SECIS-dependent UGA recoding changes\n        ├─ selected transcripts can undergo stronger repression / NMD","model_system":"Supplied reference; verify the primary study and experimental context.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c788c19c-884c-5233-92b1-0bd063d87741","stable_key":"deficiency","title":"Selenium deficiency: a mechanism-first reference","document_type":"user_supplied_reference","citation_label":"Supplied selenium deficiency reference","file_path":"X:\\metabolic-ledger\\source_material\\selenium-deficiency-reference.md","sha256":"a3f14bc3fa24c595dda830664523090a7b5bfa76e9dcf517f42f62212ceb767e","revision_id":"f8f97804-c1fb-56df-9c06-c02e36e2a5b8","review_status":"unverified_draft","notes":"Preserved verbatim. Reported study types are source labels, not independent verification."}}],"relations":[],"conflicts":[],"corrections":[],"research":null}