{"id":"34cd816c-2edf-5b62-bcdb-7a9ff364cf5a","stable_key":"d96b230c-481b-535b-930c-04eb87ec7f02:s-allylcysteine-cth-activity","predicate":"increases_tested_activity_of","statement":"SAC pretreatment increased left ventricular CSE activity in infarcted rats from 1.23 to 2.75 micromol/g protein/hour.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"baefe0c2-ba05-5cbe-8d2c-69f56cdbc58e","mechanism_event_label":"A sulfur-producing enzyme changed activity.","subject":{"id":"8c2c295d-68b3-5e62-b1a7-00fcf915e3cc","slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"},"object":{"id":"786b5f06-269c-5d1c-bc3a-0ab9f05e72d0","slug":"rat-cth","display_name":"Rat cystathionine gamma-lyase / Cth","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"baefe0c2-ba05-5cbe-8d2c-69f56cdbc58e","stable_key":"d96b230c-481b-535b-930c-04eb87ec7f02:s-allylcysteine-cth-activity-event","event_type":"observed_relationship","label":"A sulfur-producing enzyme changed activity.","description":"SAC pretreatment increased left ventricular CSE activity in infarcted rats from 1.23 to 2.75 micromol/g protein/hour.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8c2c295d-68b3-5e62-b1a7-00fcf915e3cc","slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"786b5f06-269c-5d1c-bc3a-0ab9f05e72d0","slug":"rat-cth","display_name":"Rat cystathionine gamma-lyase / Cth","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"70cc3ced-8adc-5e76-9750-e1415683455b","slug":"hydrogen-sulfide","display_name":"Hydrogen sulfide / H2S","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"acting_entity","value_text":"s-allylcysteine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"dose","value_text":"SAC 50 mg/kg/day; PAG 10 mg/kg/day","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Seven-day pretreatment; assessed 48 hours after infarction","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_comparison","value_text":"Saline, SAC, SAC plus PAG, and PAG-alone groups","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Acute myocardial infarction; left ventricular and plasma measurements","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived research curation; not independent primary verification","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"CSE is CTH; not proof that SAC is directly cleaved to H2S or that enzyme activity increases in people.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"S-allylcysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A sulfur-producing enzyme changed activity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[17766469] S-allylcysteine mediates cardioprotection in an acute myocardial infarction rat model via a hydrogen sulfide-mediated pathway. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17766469/ · DOI 10.1152/ajpheart.00853.2007","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Administration route not specified in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Acute myocardial infarction; left ventricular and plasma measurements","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9e9cbf34-58c2-5650-b484-013bd924863c","evidence_kind":"source_excerpt","locator":"Lines 239-246","start_line":239,"end_line":246,"excerpt":"## s-allylcysteine-cth-activity\nA sulfur-producing enzyme changed activity.\nSAC pretreatment increased left ventricular CSE activity in infarcted rats from 1.23 to 2.75 micromol/g protein/hour.\nModel: Acute myocardial infarction; left ventricular and plasma measurements\nLimitations: CSE is CTH; not proof that SAC is directly cleaved to H2S or that enzyme activity increases in people.\nEvidence access: Primary abstract\n[17766469] S-allylcysteine mediates cardioprotection in an acute myocardial infarction rat model via a hydrogen sulfide-mediated pathway. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17766469/ · DOI 10.1152/ajpheart.00853.2007\nStructured context: {\"organism\": \"Rattus norvegicus\", \"tissue_or_cell_type\": \"Acute myocardial infarction; left ventricular and plasma measurements\", \"dose\": \"SAC 50 mg/kg/day; PAG 10 mg/kg/day\", \"duration\": \"Seven-day pretreatment; assessed 48 hours after infarction\", \"route\": \"Administration route not specified in accessed abstract\", \"experimental_comparison\": \"Saline, SAC, SAC plus PAG, and PAG-alone groups\", \"acting_entity\": \"s-allylcysteine\", \"interpretation_status\": \"Source-derived research curation; not independent primary verification\"}","model_system":"Acute myocardial infarction; left ventricular and plasma measurements","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3b0d58f9-8a69-579d-9920-518399a9a8bb","stable_key":"import-d96b230c-481b-535b-930c-04eb87ec7f02","title":"S-allylcysteine: sulfur signaling, redox responses and cross-nutrient mechanisms (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"91d7aeac82e42ce559d13dd8a2e0165d37760f7f555dd01c80e0604fa6e71ea2","revision_id":"545e497c-e5e3-543c-b26b-b297cbc7bbec","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}