{"id":"34c0bc14-7484-5cd4-9284-4b03c84406e5","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-repeated-metabolites","predicate":"does_not_exceed_reported_normal_range","statement":"Methanol and formate remained within reported normal limits; plasma aspartate did not significantly rise in the eight-serving experiment.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"275f5f50-a530-5b9d-a540-82a96051776d","mechanism_event_label":"Products can be generated without a sustained high blood pool.","subject":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"object":{"id":"b6624e85-95a2-5ca8-9d17-a9e879088491","slug":"human-repeated-aspartame-methanol-formate","display_name":"Human blood methanol/formate during repeated aspartame ingestion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"275f5f50-a530-5b9d-a540-82a96051776d","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-repeated-metabolites-event","event_type":"observed_relationship","label":"Products can be generated without a sustained high blood pool.","description":"Methanol and formate remained within reported normal limits; plasma aspartate did not significantly rise in the eight-serving experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b6624e85-95a2-5ca8-9d17-a9e879088491","slug":"human-repeated-aspartame-methanol-formate","display_name":"Human blood methanol/formate during repeated aspartame ingestion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"96bbf620-a0f1-506b-9f01-a4f1ea1224a9","slug":"methanol","display_name":"Methanol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"1fc1fa42-fcb5-5983-9a31-114703dc64c4","slug":"formate","display_name":"Formate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"0a0923d3-72b7-5d6a-bf3a-5a7a3071a09b","slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Six healthy young adults.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Normal range is protocol- and assay-dependent, not proof that no metabolism occurred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Aspartame collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Products can be generated without a sustained high blood pool.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effect of repeated ingestion of aspartame-sweetened beverage on plasma amino acid, blood methanol, and blood formate concentrations in normal adults. · 1989 · https://pubmed.ncbi.nlm.nih.gov/2566887/ · DOI 10.1016/0026-0495(89)90125-x","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8eccea25-11e3-5531-9415-b541a5bfb8cc","evidence_kind":"source_excerpt","locator":"Lines 114-120","start_line":114,"end_line":120,"excerpt":"## aspartame-repeated-metabolites\nProducts can be generated without a sustained high blood pool.\nMethanol and formate remained within reported normal limits; plasma aspartate did not significantly rise in the eight-serving experiment.\nModel: Six healthy young adults.\nLimitations: Normal range is protocol- and assay-dependent, not proof that no metabolism occurred.\nEvidence access: Primary abstract\nEffect of repeated ingestion of aspartame-sweetened beverage on plasma amino acid, blood methanol, and blood formate concentrations in normal adults. · 1989 · https://pubmed.ncbi.nlm.nih.gov/2566887/ · DOI 10.1016/0026-0495(89)90125-x","model_system":"Six healthy young adults.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2bba7d36-993f-5ba7-acaf-2e4d573527ed","stable_key":"import-b428117d-3a8c-5e74-8711-168153e19545","title":"Aspartame: digestion, taste, metabolite dependencies and experimental signaling (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"21cfc6808062c6ea1fb5d34128bcd005d31f0f6c0d63484794238db77d32ae97","revision_id":"1255dda8-df99-5d4b-a65b-4144c47d7d9b","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}