{"id":"349cd547-a9a7-5eef-af8e-acdd8f8c0f60","stable_key":"research:methylselenol-cycling","predicate":"undergoes","statement":"Methylselenol participates in aerobic redox cycling with thioredoxin/glutaredoxin reductant systems in biochemical assays.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"literature_reviewed:direct_experimental","direction":"context_dependent","is_public":true,"mechanism_event_id":"a79e5c16-36d9-5cb8-9255-54f11d57d9b2","mechanism_event_label":"Methylselenol can cycle between redox states under suitable conditions.","subject":{"id":"a9d82119-ea7a-56ec-8cb9-6068adda19c4","slug":"methylselenol","display_name":"methylselenol","entity_type_key":"small_molecule"},"object":{"id":"ce5e6282-6104-56bc-a172-65cbae159134","slug":"methylselenol-redox-cycling","display_name":"methylselenol aerobic redox cycling","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a79e5c16-36d9-5cb8-9255-54f11d57d9b2","stable_key":"research:methylselenol-cycling","event_type":"redox_reaction","label":"Methylselenol can cycle between redox states under suitable conditions.","description":"Methylselenol participates in aerobic redox cycling with thioredoxin/glutaredoxin reductant systems in biochemical assays.","status":"active","compartment":null,"participants":[{"entity":{"id":"a9d82119-ea7a-56ec-8cb9-6068adda19c4","slug":"methylselenol","display_name":"methylselenol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ce5e6282-6104-56bc-a172-65cbae159134","slug":"methylselenol-redox-cycling","display_name":"methylselenol aerobic redox cycling","entity_type_key":"cellular_process"},"role":"object","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cell_type","value_text":"Purified reductant systems","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Purified reductant systems and cell comparisons","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Depends on generation, oxygen and reductants; not a direct prediction of cellular ROS or clinical benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Biochemical systems","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"36e838d3-783b-564d-954f-5a75cc32fd20","evidence_kind":"curated_literature_summary","locator":"lines 1420-1430","start_line":1420,"end_line":1430,"excerpt":"## methylselenol-cycling\n\nMethylselenol can cycle between redox states under suitable conditions.\n\nMethylselenol participates in aerobic redox cycling with thioredoxin/glutaredoxin reductant systems in biochemical assays.\n\nOrganism: Biochemical systems\nCell type: Purified reductant systems\nExperimental model: Purified reductant systems and cell comparisons\nLimitations: Depends on generation, oxygen and reductants; not a direct prediction of cellular ROS or clinical benefit.\nPrimary reference: [Methylselenol Formed by Spontaneous Methylation of Selenide Is a Superior Selenium Substrate to the Thioredoxin and Glutaredoxin Systems](https://pmc.ncbi.nlm.nih.gov/articles/PMC3511371/)","model_system":"Purified reductant systems and cell comparisons","directness":"author_interpretation","verification_status":"secondary_verified","notes":"Curated summary; inspect the linked primary papers for original methods and results.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4f892f13-06ea-5199-a33c-a703f35c80ae","stable_key":"selenium-research-2026-09-17","title":"Selenium: literature corrections and mechanism additions","document_type":"curated_literature_review","citation_label":"Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually","file_path":"","sha256":"0b818b10c1c7120e5caf7f4d4019d7bd025d745692e424f515d3ef903c9ab7f3","revision_id":"80984e03-5f0f-5877-8094-afef7637444e","review_status":"secondary_verified","notes":"Secondary curated summaries of primary experiments, with explicit models and limitations. Not archived primary full text."}}],"relations":[],"conflicts":[],"corrections":[{"id":"6482971e-2482-502b-a4b7-34fc19c80c32","title":"Methylselenol can undergo redox cycling","kind":"contradiction","status":"corrected","why":"Direct reductant-system assays contradict barely redox cycles.","resolution":"Specify generation, oxygen and reductants; biochemical cycling alone does not predict intracellular ROS.","created_at":"2026-09-17 07:19:34","record_type":"correction","display_label":"Correction history","record_url":"/corrections/6482971e-2482-502b-a4b7-34fc19c80c32","literature_review":{"revision_id":"80984e03-5f0f-5877-8094-afef7637444e","start_line":1676,"end_line":1681,"papers":[{"paper_key":"methylselenol-2012","title":"Methylselenol Formed by Spontaneous Methylation of Selenide Is a Superior Selenium Substrate to the Thioredoxin and Glutaredoxin Systems","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3511371/","doi":"10.1371/journal.pone.0050727","year":2012,"model":"Purified reductant systems and cell comparisons","summary":"Aerobic redox cycling demonstrated; intracellular ROS readouts need separate interpretation."}]},"sides":[{"conflict_id":"6482971e-2482-502b-a4b7-34fc19c80c32","ordinal":0,"label":"Original preserved statement","revision_id":"1fa1ebde-141f-5d47-8a4f-ba87ff84a6c6","start_line":175,"end_line":175,"quote":"Methylselenol does *not* redox cycle the way selenite does. Instead it directly:","claim_id":null,"source_key":"molecular","source_title":"Selenium: the molecular cascade","claim_ids":[]},{"conflict_id":"6482971e-2482-502b-a4b7-34fc19c80c32","ordinal":1,"label":"Original preserved statement","revision_id":"4cec6304-35d7-5560-9133-e6ea689db838","start_line":282,"end_line":282,"quote":"Methylselenol **barely redox cycles.** It acts as a **soft nucleophile / Se-electrophile pair** that directly modifies protein cysteines:","claim_id":null,"source_key":"corrections","source_title":"Selenium corrections and deep dive","claim_ids":[]},{"conflict_id":"6482971e-2482-502b-a4b7-34fc19c80c32","ordinal":2,"label":"Literature correction and experimental limits","revision_id":"80984e03-5f0f-5877-8094-afef7637444e","start_line":1676,"end_line":1681,"quote":"## Methylselenol can undergo redox cycling\n\nDirect reductant-system assays contradict barely redox cycles.\n\nSpecify generation, oxygen and reductants; biochemical cycling alone does not predict intracellular ROS.\nPrimary reference: [Methylselenol Formed by Spontaneous Methylation of Selenide Is a Superior Selenium Substrate to the Thioredoxin and Glutaredoxin Systems](https://pmc.ncbi.nlm.nih.gov/articles/PMC3511371/)","claim_id":null,"source_key":"selenium-research-2026-09-17","source_title":"Selenium: literature corrections and mechanism additions","claim_ids":[]}]}],"research":{"topic":"Selenium scientific audit","plain_language":"Methylselenol can cycle between redox states under suitable conditions.","evidence_scope":"direct_experimental","papers":[{"key":"methylselenol-2012","title":"Methylselenol Formed by Spontaneous Methylation of Selenide Is a Superior Selenium Substrate to the Thioredoxin and Glutaredoxin Systems","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3511371/","doi":"10.1371/journal.pone.0050727","year":2012,"model":"Purified reductant systems and cell comparisons","summary":"Aerobic redox cycling demonstrated; intracellular ROS readouts need separate interpretation."}]}}