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(2013). https://pubmed.ncbi.nlm.nih.gov/23153560/ DOI: 10.1016/j.taap.2012.10.029","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"CYP3A phenotyping with midazolam","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b002e451-9a92-5674-a2b9-f391a95528e7","evidence_kind":"source_excerpt","locator":"Lines 1269-1280","start_line":1269,"end_line":1280,"excerpt":"### sulforaphane-cyp3a4-alone-null\nSulforaphane alone did not change CYP3A activity in the cohort overall; a high-baseline subgroup showed increased midazolam exposure.\nCondition category: normal\nnutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: An average null and an exploratory subgroup signal must both remain visible.\norganism: Human, 24 healthy adults; humanized-PXR mouse parallel study\ntissue_or_cell_type: CYP3A phenotyping with midazolam\nexperimental_model: Three-arm randomized crossover trial\nlimitations: Average null result does not exclude individual or other-drug interactions; high-baseline subgroup finding is not a dosing rule.\nexposure: Rifampicin 300 mg/day, with or without sulforaphane 450 micromol/day for seven days; sulforaphane alone\nevidence_span: {\"source_cache\": \"artifacts/sulforaphane-research/23153560.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e13099fede346485f6e468497ff2a4754fcae4d0203dde7f54fc9643c0599fec\", \"start_char\": 0, \"end_char\": 1664, \"text_sha256\": \"e13099fede346485f6e468497ff2a4754fcae4d0203dde7f54fc9643c0599fec\"}\n[sulforaphane-p23153560] Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo. 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