{"id":"33fe629e-a75b-5052-b5bc-6b718d204dad","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-trans-dietary-deficiency-uptake","predicate":"does_not_change","statement":"Dietary pantothenate level did not change mouse intestinal pantothenate uptake assayed at 5 micromolar, including comparisons involving pantothenate-deficient diets.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"4bb4367d-9429-5d98-8bf9-aa916e729396","mechanism_event_label":"Low dietary B5 did not cause a clear increase in intestinal B5 uptake at the tested concentration.","subject":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"object":{"id":"e4e08086-40ba-5de2-b562-cb174c1e7185","slug":"mouse-intestinal-pantothenate-uptake","display_name":"Mouse intestinal pantothenate uptake","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4bb4367d-9429-5d98-8bf9-aa916e729396","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-trans-dietary-deficiency-uptake-event","event_type":"biochemical_relationship","label":"Low dietary B5 did not cause a clear increase in intestinal B5 uptake at the tested concentration.","description":"Dietary pantothenate level did not change mouse intestinal pantothenate uptake assayed at 5 micromolar, including comparisons involving pantothenate-deficient diets.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"role":"restricted_dietary_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e4e08086-40ba-5de2-b562-cb174c1e7185","slug":"mouse-intestinal-pantothenate-uptake","display_name":"Mouse intestinal pantothenate uptake","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mice fed pantothenic-acid-deficient, normal or high-pantothenic-acid diets; intestinal uptake assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"High, normal and deficient pantothenate diets; uptake assayed at 5 micromolar. An antibiotic was needed to elicit severe deficiency; exact diet amounts and antibiotic are not reported in the abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The abstract also describes a small late-deficiency increase in Vmax. A null result at 5 micromolar does not rule out all transport adaptation. Antibiotic use complicates attribution and does not quantify the human microbiome contribution.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Low dietary B5 did not cause a clear increase in intestinal B5 uptake at the tested concentration.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b5-trans-diet1989] Do dietary levels of pantothenic acid regulate its intestinal uptake in mice? (1989). https://pubmed.ncbi.nlm.nih.gov/2621490/ DOI: 10.1093/jn/119.12.1973","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Small intestine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"f0ca5fa8-2cfa-5280-abd5-083ac12251bc","evidence_kind":"source_excerpt","locator":"Lines 262-273","start_line":262,"end_line":273,"excerpt":"### b5-trans-dietary-deficiency-uptake\nDietary pantothenate level did not change mouse intestinal pantothenate uptake assayed at 5 micromolar, including comparisons involving pantothenate-deficient diets.\nCondition category: nutrient_deficiency\nnutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Low dietary B5 did not cause a clear increase in intestinal B5 uptake at the tested concentration.\norganism: Mus musculus\ntissue_or_cell_type: Small intestine\nexperimental_model: Mice fed pantothenic-acid-deficient, normal or high-pantothenic-acid diets; intestinal uptake assays\nlimitations: The abstract also describes a small late-deficiency increase in Vmax. A null result at 5 micromolar does not rule out all transport adaptation. Antibiotic use complicates attribution and does not quantify the human microbiome contribution.\nexposure: High, normal and deficient pantothenate diets; uptake assayed at 5 micromolar. An antibiotic was needed to elicit severe deficiency; exact diet amounts and antibiotic are not reported in the abstract.\ncross_nutrient: false\n[b5-trans-diet1989] Do dietary levels of pantothenic acid regulate its intestinal uptake in mice? (1989). https://pubmed.ncbi.nlm.nih.gov/2621490/ DOI: 10.1093/jn/119.12.1973","model_system":"Mice fed pantothenic-acid-deficient, normal or high-pantothenic-acid diets; intestinal uptake assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b5-trans-diet1989] Do dietary levels of pantothenic acid regulate its intestinal uptake in mice? (1989). https://pubmed.ncbi.nlm.nih.gov/2621490/ DOI: 10.1093/jn/119.12.1973","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0716b500-dd0b-5425-b9d0-d88bc9c09e86","stable_key":"import-f992b796-377d-53bf-a39b-7e5d41dbe194","title":"Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b5a49f5a2373ca6064c9a4e014e052dad2f6f199a82bb09b26b82b831c36110b","revision_id":"78f3e793-f084-5ee2-8703-b661c4b650bf","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}