{"id":"33bb87dc-206a-5530-8228-a832cce99758","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-mci-2026-exposure","predicate":"produces_measured_exposure","statement":"Completers in the 2026 trial had mean serum lithium 0.17 mEq/L, with substantial variability.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"624afd01-fb88-5d48-8daa-08ca6a551861","mechanism_event_label":"The actual exposure matters when comparing trials.","subject":{"id":"bb5db13c-d287-5847-93b2-98ab0d023797","slug":"lithium-carbonate","display_name":"Lithium carbonate","entity_type_key":"small_molecule"},"object":{"id":"57835bde-69fc-5cc2-b68e-1254c4db4da6","slug":"human-serum-lithium","display_name":"Human serum lithium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"624afd01-fb88-5d48-8daa-08ca6a551861","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-mci-2026-exposure-event","event_type":"observed_relationship","label":"The actual exposure matters when comparing trials.","description":"Completers in the 2026 trial had mean serum lithium 0.17 mEq/L, with substantial variability.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bb5db13c-d287-5847-93b2-98ab0d023797","slug":"lithium-carbonate","display_name":"Lithium carbonate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"57835bde-69fc-5cc2-b68e-1254c4db4da6","slug":"human-serum-lithium","display_name":"Human serum lithium concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mean daily carbonate dose 195 mg; serum SD 0.13 mEq/L among completers.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Completer exposure is not the whole randomized population or a recommended target.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"The actual exposure matters when comparing trials.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Low-Dose Lithium for Mild Cognitive Impairment: A Pilot Randomized Clinical Trial. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41770546/ · DOI 10.1001/jamaneurol.2026.0072","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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