{"id":"33b88988-d8ac-56c8-9520-f2b014c9b4f3","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:cyclosporine-lowers-renal-magnesium-reabsorption","predicate":"reduces","statement":"Renal magnesium loss is a well-known effect of cyclosporine treatment in people, and in this rat model the authors attribute it to downregulation of TRPM6 in the distal convoluted tubule.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"845c0fbe-a14e-5ee1-bdbc-8d95659c5136","mechanism_event_label":"Renal magnesium loss is a well-known effect of cyclosporine treatment in people, and in this rat model the authors attribute it to downregulation of TRPM6 in the distal convoluted tubule.","subject":{"id":"b199063a-fae6-5c5c-9cb4-22c10453bbac","slug":"cyclosporine","display_name":"Cyclosporine","entity_type_key":"drug"},"object":{"id":"66e1e9be-15e3-5431-9f49-b07ae3a99b5a","slug":"renal-magnesium-reabsorption","display_name":"Renal magnesium reabsorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"845c0fbe-a14e-5ee1-bdbc-8d95659c5136","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:cyclosporine-lowers-renal-magnesium-reabsorption-event","event_type":"observed_intervention","label":"Renal magnesium loss is a well-known effect of cyclosporine treatment in people, and in this rat model the authors attribute it to downregulation of TRPM6 in the distal convoluted tubule.","description":"Renal magnesium handling","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b199063a-fae6-5c5c-9cb4-22c10453bbac","slug":"cyclosporine","display_name":"Cyclosporine","entity_type_key":"drug"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"66e1e9be-15e3-5431-9f49-b07ae3a99b5a","slug":"renal-magnesium-reabsorption","display_name":"Renal magnesium reabsorption","entity_type_key":"cellular_process"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat model of cyclosporine nephrotoxicity, with the human observation as the stated background","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Cyclosporine, dose and duration not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The human magnesium loss is cited as established background in this report rather than measured in it. The rat measurement is the transporter expression and the fractional excretion, and the causal attribution between them is the authors' reading.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Rat model of cyclosporine nephrotoxicity, with the human observation as the stated background","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Renal magnesium loss is a well-known effect of cyclosporine treatment in people, and in this rat model the authors attribute it to downregulation of TRPM6 in the distal convoluted tubule.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Expression of renal distal tubule transporters TRPM6 and NCC in a rat model of cyclosporine nephrotoxicity and effect of EGF treatment. (2011). https://pubmed.ncbi.nlm.nih.gov/21653632/ DOI: 10.1152/ajprenal.00116.2011","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vivo","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Renal magnesium handling","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e513f573-4b64-598e-9211-b64690ac0c46","evidence_kind":"source_excerpt","locator":"Lines 300-300","start_line":300,"end_line":300,"excerpt":"Renal magnesium loss is a well-known effect of cyclosporine treatment in people, and in this rat model the authors attribute it to downregulation of TRPM6 in the distal convoluted tubule.","model_system":"Rat model of cyclosporine nephrotoxicity, with the human observation as the stated background","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"6b2b7746-fc66-5491-b896-e6261df254c9","stable_key":"import-1bbf9d44-8d2b-5b35-8f82-f6876558b0b3","title":"Cyclosporine: the complex that inhibits calcineurin, a second cyclophilin, and the transport step that decides exposure (2026-09-23)","document_type":"imported_text","citation_label":"Original AI-assisted curation of seven primary studies resolved by PubMed title search, with every abstract read and all DOIs cross-checked against live PubMed metadata on 2026-09-23. No reference carries a recorded retraction, erratum or expression of concern. Each of the seven is a separate laboratory and each carries its own lineage key, so none of them can be counted twice as independent support. Study-specific concentrations, kinetic constants and limitations retained. Not publisher full text.","file_path":"","sha256":"499d00555a629cba2271c3888d7e93627949891d565c4c78c843610de2913080","revision_id":"263ee68a-4184-51d0-a977-197d7ddb7a4d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}