{"id":"33a680ab-de48-5143-a3b9-6fa09432ba06","stable_key":"e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff:nasunin-thbs1-cd36","predicate":"signals_through","statement":"Neutrophil-derived THBS1 engaged macrophage CD36 in the reported pathway.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"27401229-f914-5b12-8564-d8a8ce6e5f50","mechanism_event_label":"One cell type can influence another through a secreted protein.","subject":{"id":"b9d5234f-9df7-584d-8546-0d27a3a015cb","slug":"mouse-thbs1","display_name":"Mouse thrombospondin-1 / Thbs1","entity_type_key":"protein"},"object":{"id":"98f1fe60-4f89-5d3f-830a-d1f61988a90c","slug":"mouse-cd36","display_name":"Mouse fatty-acid translocase / Cd36","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"27401229-f914-5b12-8564-d8a8ce6e5f50","stable_key":"e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff:nasunin-thbs1-cd36-event","event_type":"biochemical_relationship","label":"One cell type can influence another through a secreted protein.","description":"Neutrophil-derived THBS1 engaged macrophage CD36 in the reported pathway.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b9d5234f-9df7-584d-8546-0d27a3a015cb","slug":"mouse-thbs1","display_name":"Mouse thrombospondin-1 / Thbs1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"98f1fe60-4f89-5d3f-830a-d1f61988a90c","slug":"mouse-cd36","display_name":"Mouse fatty-acid translocase / Cd36","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/nasunin-research/41407214.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e0958157d5bc8c5df908b6d7ff18348c83726b06b63d2dc6953ebfd2ffdf0a08\", \"start_char\": 0, \"end_char\": 1949, \"text_sha256\": \"e0958157d5bc8c5df908b6d7ff18348c83726b06b63d2dc6953ebfd2ffdf0a08\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse transfer/ablation experiments, cell assays and virtual screening","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Nasunin intervention reported; exact regimen and binding validation unavailable in the indexed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"New preclinical study: virtual screening nomination is not a measured binding affinity. The pathway findings and treatment outcomes are retained separately. No human efficacy or dose inference.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Nasunin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Type 2 diabetic and control mice; mouse primary-cell models","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"One cell type can influence another through a secreted protein.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[nasunin-p41407214] Neutrophil-derived thrombospondin-1 (THBS1) drives type 2 diabetes-induced osteoporosis via CD36-PPARγ-POU2F2 signaling. (2026). https://pubmed.ncbi.nlm.nih.gov/41407214/ DOI: 10.1016/j.bbadis.2025.168139","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Neutrophil-to-macrophage signaling and osteoclastogenesis","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8458e927-b154-5e58-969b-47fe86bf1ac0","evidence_kind":"source_excerpt","locator":"Lines 419-430","start_line":419,"end_line":430,"excerpt":"### nasunin-thbs1-cd36\nNeutrophil-derived THBS1 engaged macrophage CD36 in the reported pathway.\nCondition category: normal\nnutrient_topic: Nasunin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: One cell type can influence another through a secreted protein.\norganism: Type 2 diabetic and control mice; mouse primary-cell models\ntissue_or_cell_type: Neutrophil-to-macrophage signaling and osteoclastogenesis\nexperimental_model: Mouse transfer/ablation experiments, cell assays and virtual screening\nlimitations: New preclinical study: virtual screening nomination is not a measured binding affinity. The pathway findings and treatment outcomes are retained separately. No human efficacy or dose inference.\nexposure: Nasunin intervention reported; exact regimen and binding validation unavailable in the indexed abstract\nevidence_span: {\"source_cache\": \"artifacts/nasunin-research/41407214.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e0958157d5bc8c5df908b6d7ff18348c83726b06b63d2dc6953ebfd2ffdf0a08\", \"start_char\": 0, \"end_char\": 1949, \"text_sha256\": \"e0958157d5bc8c5df908b6d7ff18348c83726b06b63d2dc6953ebfd2ffdf0a08\"}\n[nasunin-p41407214] Neutrophil-derived thrombospondin-1 (THBS1) drives type 2 diabetes-induced osteoporosis via CD36-PPARγ-POU2F2 signaling. (2026). https://pubmed.ncbi.nlm.nih.gov/41407214/ DOI: 10.1016/j.bbadis.2025.168139","model_system":"Mouse transfer/ablation experiments, cell assays and virtual screening","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [nasunin-p41407214] Neutrophil-derived thrombospondin-1 (THBS1) drives type 2 diabetes-induced osteoporosis via CD36-PPARγ-POU2F2 signaling. (2026). https://pubmed.ncbi.nlm.nih.gov/41407214/ DOI: 10.1016/j.bbadis.2025.168139","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2c43df19-ccb0-58f1-b9a4-bc92cda6de5a","stable_key":"import-e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff","title":"Nasunin: identity, redox chemistry and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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