{"id":"339caf09-0747-560b-9a48-05a20ee30449","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-glp1-null","predicate":"did_not_significantly_change","statement":"Isolated CGA did not significantly alter the overall GLP-1 response.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5e9be0f6-ae74-50c0-b9c0-ae45ec740410","mechanism_event_label":"An incretin-stimulation claim needs to acknowledge this human null result.","subject":{"id":"705c7f84-5840-55e1-be69-383cc8793a06","slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"},"object":{"id":"9086d887-f5ea-5dfb-a68f-adb2c2bda3c7","slug":"plasma-glp1-response","display_name":"Plasma GLP-1 response in the specified meal or glucose challenge","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5e9be0f6-ae74-50c0-b9c0-ae45ec740410","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-glp1-null-event","event_type":"observed_intervention","label":"An incretin-stimulation claim needs to acknowledge this human null result.","description":"Isolated CGA did not significantly alter the overall GLP-1 response.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"705c7f84-5840-55e1-be69-383cc8793a06","slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9086d887-f5ea-5dfb-a68f-adb2c2bda3c7","slug":"plasma-glp1-response","display_name":"Plasma GLP-1 response in the specified meal or glucose challenge","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chlorogenic_acid-research/21299855.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"9a6f69bf52ab0f7823e1cc585e4565765348c7a3e9bab03a88a0e7cb020306c3\", \"start_char\": 0, \"end_char\": 1086, \"text_sha256\": \"9a6f69bf52ab0f7823e1cc585e4565765348c7a3e9bab03a88a0e7cb020306c3\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized crossover glucose-challenge study in 15 overweight men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"1 g CGA, 12 g decaffeinated coffee, 500 mg trigonelline or placebo","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Acute small male-only study; coffee and isolated ingredients are separate exposures. 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(2011). https://pubmed.ncbi.nlm.nih.gov/21299855/ DOI: 10.1186/1743-7075-8-10","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma incretin responses during OGTT","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6b1dc548-f0f0-5674-a31f-de532c7f5038","evidence_kind":"source_excerpt","locator":"Lines 893-904","start_line":893,"end_line":904,"excerpt":"### chlorogenic_acid-glp1-null\nIsolated CGA did not significantly alter the overall GLP-1 response.\nCondition category: normal\nnutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: An incretin-stimulation claim needs to acknowledge this human null result.\norganism: Human\ntissue_or_cell_type: Plasma incretin responses during OGTT\nexperimental_model: Randomized crossover glucose-challenge study in 15 overweight men\nlimitations: Acute small male-only study; coffee and isolated ingredients are separate exposures. No overall incretin effect is not proof of zero effect at every dose or duration.\nexposure: 1 g CGA, 12 g decaffeinated coffee, 500 mg trigonelline or placebo\nevidence_span: {\"source_cache\": \"artifacts/chlorogenic_acid-research/21299855.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"9a6f69bf52ab0f7823e1cc585e4565765348c7a3e9bab03a88a0e7cb020306c3\", \"start_char\": 0, \"end_char\": 1086, \"text_sha256\": \"9a6f69bf52ab0f7823e1cc585e4565765348c7a3e9bab03a88a0e7cb020306c3\"}\n[chlorogenic_acid-p21299855] Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on incretin hormones. 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