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mouse tumor experiments provide a separate translational level.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not merge all tumor-cell death into one obligatory linear chain.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Cucurbitacins collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"cucurbitacin","display_name":"Cucurbitacins","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Inflammatory membrane rupture is separate from ferroptotic lipid damage.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis. · 2021 · https://pubmed.ncbi.nlm.nih.gov/34217831/ · DOI 10.1016/j.phrs.2021.105748","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fb6b65ef-ef28-5fc6-a73a-c297a3788be4","evidence_kind":"source_excerpt","locator":"Lines 300-306","start_line":300,"end_line":306,"excerpt":"## cucurbitacin-b-pyroptosis-route\nInflammatory membrane rupture is separate from ferroptotic lipid damage.\nCucurbitacin B exposure was associated with the TLR4/mitochondrial-ROS/NLRP3 route and gasdermin D cleavage in the NSCLC pyroptosis experiments.\nModel: Human NSCLC cells; 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