{"id":"33671ebb-76af-5e82-8bce-9c3c39c37dd4","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-human-metabolic-null","predicate":"did_not_improve","statement":"In a randomized 24-man obesity trial, 1,500 mg/day resveratrol for four weeks did not improve clamp-measured insulin sensitivity, glucose turnover, ectopic fat or the measured metabolic/inflammatory outcomes.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"12d8e919-a586-593b-af49-bc9220928f40","mechanism_event_label":"A larger dose did not reproduce a universal metabolic benefit.","subject":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"0ae0d09f-98f3-547e-bf81-cf0b5671c01d","slug":"human-resveratrol-clamp-insulin-sensitivity","display_name":"Human clamp-measured insulin sensitivity after resveratrol","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"12d8e919-a586-593b-af49-bc9220928f40","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-human-metabolic-null-event","event_type":"observed_relationship","label":"A larger dose did not reproduce a universal metabolic benefit.","description":"In a randomized 24-man obesity trial, 1,500 mg/day resveratrol for four weeks did not improve clamp-measured insulin sensitivity, glucose turnover, ectopic fat or the measured metabolic/inflammatory outcomes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0ae0d09f-98f3-547e-bf81-cf0b5671c01d","slug":"human-resveratrol-clamp-insulin-sensitivity","display_name":"Human clamp-measured insulin sensitivity after resveratrol","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Parallel placebo-controlled trial in otherwise healthy obese men.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Different dose, design and endpoints from the 11-person crossover; difference alone is not a scientific contradiction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A larger dose did not reproduce a universal metabolic benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23193181/ · DOI 10.2337/db12-0975","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"95dca9fd-1ec7-548a-944b-e3dfdd9ebbdc","evidence_kind":"source_excerpt","locator":"Lines 462-468","start_line":462,"end_line":468,"excerpt":"## resveratrol-human-metabolic-null\nA larger dose did not reproduce a universal metabolic benefit.\nIn a randomized 24-man obesity trial, 1,500 mg/day resveratrol for four weeks did not improve clamp-measured insulin sensitivity, glucose turnover, ectopic fat or the measured metabolic/inflammatory outcomes.\nModel: Parallel placebo-controlled trial in otherwise healthy obese men.\nLimitations: Different dose, design and endpoints from the 11-person crossover; difference alone is not a scientific contradiction.\nEvidence access: Primary full text\nHigh-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23193181/ · DOI 10.2337/db12-0975","model_system":"Parallel placebo-controlled trial in otherwise healthy obese men.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"04885b4bee72f912a7f3f618f1b2bf79c944dbcb20500398c2729fc8228dcd9a","revision_id":"99504ff2-f1d3-5f4c-bc31-e1030d27a918","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}